Organometallics in Process Chemistry
(Sprache: Englisch)
The design of efficient syntheses of medicinal agents is one of the prime goals of the process chemist in the pharmaceutical industry. The expanding list of metal-mediated reactions has had a major impact on this endeavor over the last two decades. This...
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The design of efficient syntheses of medicinal agents is one of the prime goals of the process chemist in the pharmaceutical industry. The expanding list of metal-mediated reactions has had a major impact on this endeavor over the last two decades. This volume will highlight some of the areas of organometallic chemistry that have played a particularly important role in development. The chapters are written by chemists who work in the process groups of major pharmaceutical companies and fine chemical manufacturers. Having demonstrated the power of organometallics in their processes the authors herein expand upon their experiences with examples from the literature as reported by process groups within the industry. The chapters are organized either by the application of a particular metal or reaction class. Removal of the residual metal(s) from the isolated active pharmaceutical ingredient (API) is key to the release of the material for human consumption, and hence, is reviewed here as well. This volume of Topics in Organometallic Chemistry is presented to offer a representative cross section of organometallic applications in the pharmaceutical industry as well as to give an appreciation for the creativity possible in process chemistry.
Inhaltsverzeichnis zu „Organometallics in Process Chemistry “
George G. Wu, Mingsheng Huang: Organolithium in Asymmetric Processes- David L. Hughes: Applications of Organotitanium Reagents
- Kenzo Sumi, Hidenori Kumobayashi: Rhodium/Ruthenium Applications
- Albert J. Delmonte, Eric D. Dowdy, Daniel J. Watson: Development of Transition Metal-Mediated Cyclopropanation Reaction
- Jay F. Larrow, Eric N. Jacobsen: Asymmetric Processes Catalyzed by Chiral (Salen) Metal Complexes
- Steven J. Mehrman, Ahmed F. Abdel-Magid, Cynthia A. Maryanoff, Bart P. Medaer: Non-Salen Metal-Catalyzed Asymmetric Dihydroxylation and Asymmetric Aminohydroxylation of Alkenes. Practical Applications and Recent Advances
- Mahavir Prashad: Palladium-Catalyzed Heck Arylations in the Synthesis of Active Pharmaceutical Ingredients
- Anthony O. King, Nobuyoshi Yasuda: Palladium-Catalyzed Cross Coupling Reactions in the Synthesis of Pharmaceuticals
- Jeffrey Bien, Gregory C. Lane, Matthew R. Oberholzer: Removal of Metals from Process Streams: Methodologies and Applications.
Bibliographische Angaben
- 2004, 286 Seiten, Maße: 16 x 24,1 cm, Gebunden, Englisch
- Herausgegeben:Larsen, Rob
- Herausgegeben: Rob Larsen
- Verlag: Springer
- ISBN-10: 3540016031
- ISBN-13: 9783540016038
- Erscheinungsdatum: 15.06.2004
Sprache:
Englisch
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