Oxidative Neural Injury
(Sprache: Englisch)
This book examines the current evidence and research supporting the importance of oxidative injury in selected animal models of both neurodegenerative diseases and neural injury. Each chapter discusses oxidative injury in a selected model, analyzing the...
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This book examines the current evidence and research supporting the importance of oxidative injury in selected animal models of both neurodegenerative diseases and neural injury. Each chapter discusses oxidative injury in a selected model, analyzing the major cellular mechanisms that underpin the progression of neural injury. In addition to the analysis of these models, each chapter's purpose is to not only relate, but to also contrast the specific injury across models as a way of identifying the common and unique pathways of oxidative neural injury. Through this, each author presents possible fertile future directions for translational research for the identification of possible therapeutics.
Klappentext zu „Oxidative Neural Injury “
Twenty-five years ago, Earl R. Stadtman, PhD discovered that specific enzymes regulating metabolism can be inactivated by oxidation [1]. He later showed that age-related oxidative modification contributes, at least in part, to age-related loss of function of the enzymes [2, 3]. Dr. Stadtman broke the ground for a new field of study to discover how oxidative stress contributes in significant ways to age-related cellular dysfunction and protein accumulation and that oxidation in the aging brain influences Alzheimer's disease, ischemia-reperfusion injury, amyotrophic lateral sclerosis, and lifespan [4-6]. Today, his research and mentorship have positively influenced the work of hundreds of scientists in this field. We dedicate this book to Dr. Earl R. Stadtman (1912-2008), in celebration of his passion for science and his superior collaborative and mentorship skills. This book is comprised of three sections. The first describes the valuable roles reactive oxygen species (ROS) and reactive nitrogen species (RNS) play in cellular biology. The second section provides an overview of redox imbalance injury with effects on mitochondria, signaling, endoplasmic reticular function, and on aging in general. The third section takes these mechanisms to neurodegenerative disorders and provides a state-of-the-art look at the roles redox imbalances play in age-related susceptibility to disease and in the disease processes. In the first section we attempt to answer a question posed by Dr. Stadtman, ''Why have cells selected reactive oxygen species to regulate cell signaling events'' [7].
Inhaltsverzeichnis zu „Oxidative Neural Injury “
Chapter 1 and 2: Basic Redox (reactive oxygen/nitrogen species) Biochemistry Andrew Gow (Andrew Gow, 160 Frelinghuysen Rd, Piscataway, NJ 08540; e-mail: gow@rci.rutgers.edu.) Harry Isciropoulos (Research Professor of Pediatrics and Pharmacology 416D Abramson Research Center (215)590-5320 E-mail: ischirop@mail.med.upenn.edu)Chapter 3: Areas of neuronal loss in hypoixa/reoxygenation oxidative injury Andrey Y. Abramov,1 Department of Physiology, University College London, London WC1E 6BT, United Kingdom, a.abramov@ucl.ac.uk
Chapter 4: How oxidative injury translates into unfolded protein response-induced cellular dysfunction Constantinos Koumenis, Ph.D University of Pennsylvania, Department of Radiation Oncology koumenis@xrt.upenn.edu
Chapter 5: Mitochondrial injury as a source of oxidative injury to neurons in amyotrophic lateral sclerosis Lee J. Martin, PhD, Johns Hopkins University School of Medicine, Department of Pathology, 558 Ross Building, 720 Rutland Avenue, Baltimore, MD; E-mail: martinl@jhmi.edu
Chapter 6: Oxidative injury to the autonomic nervous system Costantino Iadecola MD Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, NY 10021, coi2001@med.cornell.edu
Chapter 7: Excitatory neurotoxicity and ER stress component (Therapeutics part) Dr. Laura Korhonen, Minerva Medical Research Institute, Biomedicum Helsinki, Haartmaninkatu 8, FIN-00290 Helsinki, Finland. Email: Laura.T.Korhonen@helsinki.fi
Chapter 8: Excitatory neurotoxicity and ER stress component (Therapeutics part) Don Cleveland, Ludwig Institute for Cancer Research and Departments of Medicine and Neuroscience, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA dcleveland@ucsd.edu
Chapter 9: ROS and brain injury in alzheimer's D. Allan Butterfield, Department of Chemistry, Center of Membrane Sciences, University of Kentucky, Lexington, KY 40506-0055 dabcns@uky.edu
Chapter 10: Oxidative neural injury in Parkinson's
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D.A. Di Monte, The Parkinson's Institute, Basic Research Department, 1170 Morse Avenue, Sunnyvale, CA 94089, USA ddimonte@thepi.org
Chapter 11: Oxidative neural injury in sleep apnea David Gozal, MD. Professor of Pediatrics, Vice Chair of Research University of Louisville david.gozal@louisville.edu
Chapter 12: PPAR oxidative response in neurodegenerative disorders Bruce M. Spiegelman1, , Department of Neurology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA bruce_spiegelman@dfci.harvard.edu
Chapter 13: Neuronal injury and oxidative across disease Mark P Mattson Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland 21224, USA. mattsonm@grc.nia.nih.govin injury in alzheimer's D. Allan Butterfield, Department of Chemistry, Center of Membrane Sciences, University of Kentucky, Lexington, KY 40506-0055 dabcns@uky.edu
Chapter 11: Oxidative neural injury in sleep apnea David Gozal, MD. Professor of Pediatrics, Vice Chair of Research University of Louisville david.gozal@louisville.edu
Chapter 12: PPAR oxidative response in neurodegenerative disorders Bruce M. Spiegelman1, , Department of Neurology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA bruce_spiegelman@dfci.harvard.edu
Chapter 13: Neuronal injury and oxidative across disease Mark P Mattson Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland 21224, USA. mattsonm@grc.nia.nih.govin injury in alzheimer's D. Allan Butterfield, Department of Chemistry, Center of Membrane Sciences, University of Kentucky, Lexington, KY 40506-0055 dabcns@uky.edu
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Bibliographische Angaben
- 2010, XIV, 218 Seiten, Maße: 15,6 x 23,4 cm, Kartoniert (TB), Englisch
- Herausgegeben: Sigrid C. Veasey
- Verlag: Springer, Berlin
- ISBN-10: 1617378925
- ISBN-13: 9781617378928
Sprache:
Englisch
Rezension zu „Oxidative Neural Injury “
From the reviews: "This book addresses how oxidative stress contributes to age-related cellular dysfunction particularly in Alzheimer's ischemia, Parkinson's disease, and other neurodegenerative conditions. The book fills a niche, addressing the current molecular understanding of oxidative stress and its role in pathophysiology. ... it is most appropriate for the many neuroscientists around the world contemplating how to identify the next best approach for targeted therapy for several neurodegenerative diseases. ... the book is a good resource for libraries with PhD graduate students and molecular neuroscience laboratories." (Joseph I. Sirven, Doody's Review Service, December, 2009)
Pressezitat
From the reviews: "This book addresses how oxidative stress contributes to age-related cellular dysfunction particularly in Alzheimer's ischemia, Parkinson's disease, and other neurodegenerative conditions. The book fills a niche, addressing the current molecular understanding of oxidative stress and its role in pathophysiology. ... it is most appropriate for the many neuroscientists around the world contemplating how to identify the next best approach for targeted therapy for several neurodegenerative diseases. ... the book is a good resource for libraries with PhD graduate students and molecular neuroscience laboratories." (Joseph I. Sirven, Doody's Review Service, December, 2009)
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