Oxidative Stress and Aging

Introductory papers.- Oxidative stress, antioxidants, aging and disease.- Longevity determinant genes, cellular dysdifferentiation and oxidative stress.- Oxidative stress and cellular senescence.- Oxidative stress and apoptosis.- Superoxide and hydrogen peroxide as cellularly generated life-signals in the balance between proliferation and cell death.- Cellular aging and oxidative stress.- Cellular nitrogen oxide production: Its role in endogeneous mutation and carcinogenesis.- Vascular smooth muscle cell proliferation is controlled by d-?-tocopherol at the level of protein kinase C and of the transcription factor AP-1.- Genetic stability and damage: DNA repair.- DNA damage and epigenetic mechanisms of aging.- Formation of 8-hydroxyguanine in DNA by aging and oxidative stress.- Age-dependent DNA modifications (I-compounds): Effects of carcinogenesis and oxidative stress.- Iron-induced carcinogenesis in experimental animals: A free radical mechanism of DNA damage and carcinogenesis.- DNA repair, oxidative stress and aging.- Genetics and lifespan.- Poly(ADP-ribose) polymerase: Correlation of enzyme activity with the life span of mammalian species and use of a dominant negative version to elucidate biological functions of poly(ADP-ribosyl)ation.- Antioxidant genes and other mechanisms involved in the extended longevity of Drosophila.- Proteins and lipid oxidation.- Novel approaches toward inhibition of the Maillard reaction in vivo: Search, isolation and characterization of prokaryotic enzymes which degrade glycated substrates.- Age-associated changes of oxidative modification and turnover of proteins.- Mitochondria.- Mitochondria, free radicals, neurodegeneration and aging.- Free radicals and muscle damage due to immobilization of old animals: Effect of growth hormone.-PCR analysis of mitochondrial DNA from normal and transgenic glutathione peroxidase mice.- Aging related diseases and cancer.- Free radicals in the pathogenesis of diabetes and its complications.-