Perspecitves in Toxinology
(Sprache: Englisch)
In diesem Tagungsband stellen Ihnen die Hauptvortragenden des '13th World Congress on Animal, Plant and Microbial Toxins' neueste Entwicklungen auf ihren jeweiligen Fachgebieten vor. Das Themenspektrum reflektiert momentane Forschungsschwerpunkte - die...
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Produktinformationen zu „Perspecitves in Toxinology “
In diesem Tagungsband stellen Ihnen die Hauptvortragenden des '13th World Congress on Animal, Plant and Microbial Toxins' neueste Entwicklungen auf ihren jeweiligen Fachgebieten vor. Das Themenspektrum reflektiert momentane Forschungsschwerpunkte - die meisten Beiträge beschäftigen sich mit neuartigen Toxinen, die im Meer gefunden wurden.
Klappentext zu „Perspecitves in Toxinology “
Covering the most recent advances in our understanding of toxins from venomous animals and microbes as well as that of their targets, this book expertly addresses the many intriguing and unsolved questions concerning; proteomics studies of the "toxinome", intimate modes of toxin actions, molecular basis of specificity, pleiotropic properties of toxins and structural biology of toxins.Through twenty-seven chapters the authors discuss the role of structural genomics in toxinology, how toxins are subject to accelerated evolution, how toxins can be exploited as models for the design of new drugs, and what the future holds for the treatment of snake bites.
In order to address these challenging aspects, the authors have posed crystal-clear questions. Based on the most precise knowledge the attendant reasoning shows how toxinology has become an important area of biochemistry and is directly associated with advances in cellular microbiology, molecular pharmacology, molecular physiology, cell biology, protein engineering and many other disciplines.
Inhaltsverzeichnis zu „Perspecitves in Toxinology “
List of ContributorsPreface
I TOXINS FROM MICROORGANISMS
Bacterial Toxins with Metalloprotease Activity (O. Rossetto and C. Montecucco)
The Cholesterol-dependent Cytolysins: Current Perspectives on Membrane Assembly and Insertion (E. Hotze and R.K. Tweten)
Toxin-producing Dinoflagellates (M.J. Holmes and R. Lewis)
Involvement of Na+ in the Actions of Ciguatoxins and Brevetoxins that Stimulate Neurotransmitter Release and Affect Synaptic Transmission (J. Molgó and E. Benoit)
II ANIMAL TOXINS AND NEW METHODOLOGIES
Role of Discovery Science in Toxicology: Examples in Venom Proteomics (J.W. Fox, J.D. Shannon, B. Stefansson, A.S. Kamiguti, R.D.G. Theakston, S.M.T. Serrano, A.C.M. Camargo and N. Sherman)
Proteomics of Venom Peptides (R. Stocklin and P. Favreau)
High-resolution NMR of Venom Toxins in Nanomolar Amounts (M. Delepierre)
III ANIMAL TOXINS: FROM FUNDAMENTAL STUDIES TO DRUGS?
Cone Snails and Conotoxins Evolving Sophisticated Neuropharmacology (B.M. Olivera, J.S. Imperial and G Bulaj)
Toxin Structure and Function: What Does Structural Genomics Have To Offer? (R.S. Norton)
The Sites by which Animal Toxins Bind to their Targets Involve Two Components: A Clue for Selectivity, Evolution and Design of Proteins? (A. Ménez, D. Servent and S. Gasparini)
Scorpion Genes and Peptides Specific for Potassium Channels: Structure,Function and Evolution (L.D. Possani, E. Merino, M. Corona and B. Becerril)
Scorpion Toxins Differentiating among Neuronal Sodium Channel Subtypes: Nature's Guide for Design of Selective Drugs (D. Gordon, N. Gilles, D. Bertrand, J. Molgó, G.M. Nicholson, M.P. Sauviat, E. Benoit, I. Shichor, I. Lotan, M. Gurevitz, R.G. Kallen and S.H. Heinemann)
Diversification of Toxic Sites on a Conserved Protein Scaffold - a Scorpion Recipe for Survival (M. Gurevitz, N. Zilberberg, O. Froy, M. Turkov, R. Wilunsky, I. Karbat, J. Anglister, B. Shaanan, M. Pelhate, M.E. Adams, N. Gilles, D. Gordon)
Methodological
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Approaches to the Study of Ion Channels Using Peptide Toxins: Proposed Comprehensive Guidelines (M. De Waard, J.-M. Sabatier and H. Rochat)
Toxins as Probes for Structure and Specificity of Synaptic Target Proteins (P. Taylor, B. Molles, S. Malany and H. Osaka)
Allosteric and Steric interactions of Polyamines and Polyamine-containing Toxins with Nicotinic Acetylcholine Receptors (T.J. Brier, I.R. Mellor and P.N.R. Usherwood)
Anabaseine as a Molecular Model for Design of a7 Nicotinic Receptor Agonist Drugs (W.R. Kem)
Understanding the Structure-Function Relationship of Snake Venom Cardiotoxins (T.K.S. Kumar, S. Srisailam, R.R. Vethanayagam and C. Yu)
Structure and Function of Disintegrins and C-lectins: Viper Venom Proteins Modulating Cell Adhesion (S. Niewiarowski, C. Marcinkiewicz, I. Wierzbicka-Patynowski, M.A. McLane and J.J. Calvete)
Prothrombin Activators from Snake Venoms (R.M. Kini, J.S. Joseph and V.S. Rao)
C-type Lectins from Snake Venoms: New Tools for Research in Thrombosis and Haemostasis (A. Wisner, M. Leduc and C. Bon)
Toxins Leading to Medicines (A.L. Harvey)
IV EVOLUTION OF ANIMAL TOXINS
Accelerated and Regional Evolution of Snake Venom Gland Isozymes (M. Ohno, T. Ogawa, N. Oda-Ueda, T. Chijiwa and S. Hattori)
Functional Diversification of Animal Toxins by Adaptive Evolution (D. Kordis, I. Kriûaj and F. Gubenëek)
V FROM VENOMS TO TREATMENT
The Venomous Function (M. Goyffon)
Are Inhibitors of Metalloproteinases, Phospholipases A2 and Myotoxins Members of the Innate System? (J. Perales and G.B. Domont)
The Treatment of Snake Bites: Analysis of Requirements and Assessment of Therapeutic Efficacy in Tropical Africa (J.-P. Chippaux)
Toxins as Probes for Structure and Specificity of Synaptic Target Proteins (P. Taylor, B. Molles, S. Malany and H. Osaka)
Allosteric and Steric interactions of Polyamines and Polyamine-containing Toxins with Nicotinic Acetylcholine Receptors (T.J. Brier, I.R. Mellor and P.N.R. Usherwood)
Anabaseine as a Molecular Model for Design of a7 Nicotinic Receptor Agonist Drugs (W.R. Kem)
Understanding the Structure-Function Relationship of Snake Venom Cardiotoxins (T.K.S. Kumar, S. Srisailam, R.R. Vethanayagam and C. Yu)
Structure and Function of Disintegrins and C-lectins: Viper Venom Proteins Modulating Cell Adhesion (S. Niewiarowski, C. Marcinkiewicz, I. Wierzbicka-Patynowski, M.A. McLane and J.J. Calvete)
Prothrombin Activators from Snake Venoms (R.M. Kini, J.S. Joseph and V.S. Rao)
C-type Lectins from Snake Venoms: New Tools for Research in Thrombosis and Haemostasis (A. Wisner, M. Leduc and C. Bon)
Toxins Leading to Medicines (A.L. Harvey)
IV EVOLUTION OF ANIMAL TOXINS
Accelerated and Regional Evolution of Snake Venom Gland Isozymes (M. Ohno, T. Ogawa, N. Oda-Ueda, T. Chijiwa and S. Hattori)
Functional Diversification of Animal Toxins by Adaptive Evolution (D. Kordis, I. Kriûaj and F. Gubenëek)
V FROM VENOMS TO TREATMENT
The Venomous Function (M. Goyffon)
Are Inhibitors of Metalloproteinases, Phospholipases A2 and Myotoxins Members of the Innate System? (J. Perales and G.B. Domont)
The Treatment of Snake Bites: Analysis of Requirements and Assessment of Therapeutic Efficacy in Tropical Africa (J.-P. Chippaux)
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Bibliographische Angaben
- 2002, 1. Auflage, XXX, 486 Seiten, 14 farbige Abbildungen, Maße: 23,4 cm, Gebunden, Englisch
- Herausgegeben: André Ménez
- Verlag: Wiley & Sons
- ISBN-10: 0471495034
- ISBN-13: 9780471495031
Sprache:
Englisch
Pressezitat
"...useful not only to those in the field of toxinology, but also to any interested in dramatic examples of the applications and promise of modern techniques of molecular biology to medicine in general." ( Veterinary and Human Toxicology , Vol. 44, No. 6, December 2002)"...insightful and informative reviews...much to ponder here..." (Chemistry & Industry, (3 March 2003)
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