Pharmaceuticals in the Environment

General Aspects.- Pharmaceuticals in the Environment - A Brief Summary.- Special Characteristics of Pharmaceuticals Related to Environmental Fate.- Sources, Occurrence and Fate.- Drug Production Facilities - An Overlooked Discharge Source for Pharmaceuticals to the Environment.- Substance Flows Associated with Medical Care - Significance of Different Sources.- Pharmaceutical Residues in Northern European Environments: Consequences and Perspectives.- Antibiotics in the Environment.- Veterinary Antibiotics in Dust: Sources, Environmental Concentrations, and Possible Health Hazards.- Fate of Veterinary Medicines Applied to Soils.- Pharmaceuticals as Environmental Contaminants: Modeling Distribution and Fate.- Environmental Exposure Modeling: Application of PhATE(TM) and Great-ER to Human Pharmaceuticals in the Environment.- Exposure Assessment Methods for Veterinary and Human-Use Medicines in the Environment: PEC vs. MEC Comparisons.- Effects.- Effects of Pharmaceuticals on Aquatic Organisms.- Another Example of Effects of Pharmaceuticals on Aquatic Invertebrates: Fluoxetine and Ciprofloxacin.- Effects of Antibiotics and Virustatics in the Environment.- Realizing the Potential Benefits of Small Animal Models for the Aquatic Hazard Assessment of Human Pharmaceuticals: A Conceptual Approach.- On the Ecotoxicology of Pharmaceutical Mixtures.- Chronic Mixture Toxicity of Pharmaceuticals to Daphnia - The Example of Nonsteroidal Anti-Inflammatory Drugs.- The Ecotoxicological Effects of Pharmaceuticals (Antibiotics and Antiparasiticides) in the Terrestrial Environment - a Review.- Odorants - Potent Substances at Minor Concentrations: The Ecological Role of Infochemicals.- Risk Assessment.- European Developments in the Environmental Risk Assessment of Pharmaceuticals.-The State and the Future Development/Perspective of Environmental Risk Assessment of Medicinal Products for Human Use: Aspects of Its Regulations in Japan.- Deterministic and Probabilistic Environmental Risk

The study of pharmaceuticals in the environment is a relatively new area of research. This edition addresses the most important issues in the field for the near future. Following the resounding success of the first two editions, this new edition has been brought up-to-date and greatly extended. It includes the status of research on soil, paying particular attention to field studies in terrestrial and aquatic environments as well as new substance categories such as tetracylines and chinolones and the latest results concerning contamination of the environment and risk reduction. In line with the newest developments worldwide there are now many more contributions from international authors. This volume also caters for the new requirements confronting European and American researchers since publication of the first edition. This book provides the reader with a well-founded overview which even specialists will appreciate.

From the reviews of the third edition:

"This book gives a very good short, readable and impressive overview of the role and the fate of pharmaceuticals in the environment which was in the past totally neglected. It highlights the knowledge and the lack of knowledge of the today's fast growing research area. The book should be a standard-lecture not only for ecologists, chemists and pharmacists ... . Everybody whose work/interests stay in contact with the research ... or the application of drugs can find some suitable information in this book." (Moritz Schübler, Clean, Vol. 37 (7), 2009)