Pharmacokinetics and Metabolism in Drug Design
(Sprache: Englisch)
A concise introduction to the parameters and processes governing the absorption, distribution and retention of drug compounds in the body, now covering also modern approaches of ADME screening and evaluation.
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A concise introduction to the parameters and processes governing the absorption, distribution and retention of drug compounds in the body, now covering also modern approaches of ADME screening and evaluation.
Klappentext zu „Pharmacokinetics and Metabolism in Drug Design “
An understanding of pharmacokinetics is necessary to ensure that drugs that are active in vitro will also be active in the human body. The optimization of the pharmacokinetic properties of lead compounds is therefore of central importance to drug development. This concise introduction to the world of ADME and drug toxicity discusses the significant parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic byproducts. The authors, all employed at Pfizer in the discovery and development of new active substances, cover everything from the fundamental principles right up to the latest developments using high throughput methods to analyze the pharmacokinetic properties of active substances. Particular emphasis is placed on the impact of pharmacokinetic parameters on the discovery of new drugs - one of the most challenging tasks in global pharmaceutical research.
The medical benefits of a drug are not only dependent on its biological effect, but also on its "life cycle" within the organism - from its absorption into the blood, distribution to tissue until its eventual breakdown or excretion by the liver and kidneys.
Here, the authors, all of them employed at Pfizer in the discovery and development of new active substances, discuss the significant parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic byproducts. The authors cover everything from the fundamental principles right up to the latest developments using high throughput methods to analyze the pharmacokinetic properties of active substances.
Particular emphasis is placed on the impact of pharmacokinetic parameters on the discovery of new drugs - one of the most challenging tasks in global pharmaceutical research.
Thus, this book is aimed at all those dealing professionally with the development and application of pharmaceutical substances. Furthermore, the readily comprehensible style of writing makes it equally suitable for students of pharmacy and related subjects, who feel that pharmacokinetics is covered too briefly in the standard textbooks.
Here, the authors, all of them employed at Pfizer in the discovery and development of new active substances, discuss the significant parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic byproducts. The authors cover everything from the fundamental principles right up to the latest developments using high throughput methods to analyze the pharmacokinetic properties of active substances.
Particular emphasis is placed on the impact of pharmacokinetic parameters on the discovery of new drugs - one of the most challenging tasks in global pharmaceutical research.
Thus, this book is aimed at all those dealing professionally with the development and application of pharmaceutical substances. Furthermore, the readily comprehensible style of writing makes it equally suitable for students of pharmacy and related subjects, who feel that pharmacokinetics is covered too briefly in the standard textbooks.
Inhaltsverzeichnis zu „Pharmacokinetics and Metabolism in Drug Design “
PrefacePhysicochemistry
Pharmacokinetics
Absorption
Distribution
Clearance
Renal Clearance
Metabolic (Hepatic) Clearance
Toxicity
Inter-Species Scaling
High(er) Throughput ADME Studies
Index
Autoren-Porträt von Dennis A. Smith, Han van de Waterbeemd, Don K. Walker
The authors are leading scientists in the Drug Metabolism department of Pfizer, one of the top five pharmaceutical companies in the world.
Bibliographische Angaben
- Autoren: Dennis A. Smith , Han van de Waterbeemd , Don K. Walker
- 2006, 2nd ed., XIX, 187 Seiten, mit zahlreichen Schwarz-Weiß-Abbildungen, Maße: 25 x 53 cm, Gebunden, Englisch
- Verlag: Wiley-VCH
- ISBN-10: 3527313680
- ISBN-13: 9783527313686
Sprache:
Englisch
Rezension zu „Pharmacokinetics and Metabolism in Drug Design “
"This work will interest and inform both the beginning professional in the field of drug discovery/design and the medicinal chemist...I also highly recommend it for students..." (Journal of Medicinal Chemistry, December 14, 2006) "...extremely useful to students of Toxicology and others with an interest in the subject." (British Toxicology Society Newsletter, Summer 2007)
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