Physiologically Based Pharmacokinetic (PBPK) Modeling

Preface.

Chapter 1.Introduction: A Historical Perspective of the Development and Applications of PBPK Models.
1. Introduction.
2. A Historical Perspective.
3. Expansion of PBPK Model Applications.
4. Summary.

SECTION 1. PBPK MODELING FOR VOLATILE ORGANIC COMPOUNDS.#

Chapter 2. Halogenated Alkanes.
1. Introduction.
2. PBPK Model Development for Volatile Organics.
3. Advances in Experimental Methods Demonstrated for Groups of Chemicals.
4. PBPK Models for Halogenated Alkanes.
5. Summary.

Chapter 3. Halogenated Alkenes.
1. Introduction.
2. The Chloroethylenes: Background.
3. Review of PBPK Models.
4. Summary.

Chapter 4. Alkene and Aromatic Compounds.
1. Introduction.
2. PK and Pharmacodynamic Properties Important in PBPK Model Development for Aromatic and Alkene Compounds.
3. Review of Aromatic and Alkene PBPK Models.
4. Summary.

Chapter 5. Reactive Vapors in the Nasal Cavity.
1. Introduction.
2. No Air-Phase Models.
3. Creating the Air Phase Compartments.
4. Other Models for Vapors Affecting Nasal Tissues.
5. Methyl Methacrylate.
6. Formaldehyde.
7. Hydrogen Sulfide.

10. Summary.

Chapter 6. Alkanes, Oxyhydrocarbons and Related Compounds.
1. Introduction.
2. Purposes for PBPK Model Development.
3. PBPK Models for Four Classes of Compounds.
4. Summary.

SECTION 2. PBPK MODEL DEVELOPMENT FOR ENVIRONMENTAL POLLUTANTS.

Chapter 7. Pesticides and Persistent Organic Pollutants (POPs).
1. Introduction.
2. Pesticides.
3. Polychlorinated and Polybrominated Biphenyls, PCBs and PBBs.
4. Summary.

Chapter 8. Dioxin and Related Compounds.
1. Introduction.
2. Toxicity.
3. Mode of Action.
4. Pharmacokinetics.
5. PBPK Models of TCDD.
6. Summary.

Chapter 9. Metals and Inorganic Compounds.
1. Introduction.
2. Physiologically Based Modeling of Metals.
3. PBPK Models for Non-Metals.
4. Compartmental Models for Miscellaneous Inorganic and/or Endogenous Chemicals.
5. Research Needs.
6. Summary.

SECTION 3.

The EDITORS have worked together on PBPK research and in teaching PBPK modeling workshops and courses through the Quantitative and Computation Toxicology research group at the Center for Environ-mental Toxicology and Technology (CETT) in the Department of Environmental and Radiological Health Sciences at Colorado State University (CSU).

MICAELA B. REDDY, PhD, is a research professor at CETT where she has developed PBPK models for risk assessment and toxicology applications.

RAYMOND S. H. YANG, PhD, Professor of Toxicology and former director, CETT, championed applications of PBPK modeling in research on the toxicology of chemical mixtures.

HARVEY J. CLEWELL III, MS, Director, Center for Human Health Assessment, CIIT Centers for Health Research, Research Triangle Park, North Carolina, played a major role in the first uses of PBPK modeling in cancer and non-cancer risk assessments by several federal agencies, including EPA, ATSDR, OSHA, and FDA.

MELVIN E. ANDERSEN, PhD, a pioneer in use of PBPK modeling in toxicology and risk assessment, is Director, Computational Biology Division, CIIT Centers for Health Research, Research Triangle Park, North Carolina.

"This is a comprehensive, useful book, a valuable reference for toxicologists, regulators, pharmacologists, pharmacists, and graduate students..." (American Journal of Therapeutics, March/April 2006)

"This is a comprehensive, useful book, a valuable reference for toxicologists, regulators, pharmacologists, pharmacists, and graduate students..." ( American Journal of Therapeutics , March/April 2006)