Prenatal stress. Long-term Effects of Psychobiological Reactivity on Acute Psychosocial Stress and Anxiety in Ten-year-old-children

Various lines of research in animals and humans indicate that prenatal stress can have long-lasting effects on biological and psychological processes of the offspring. In particular, prenatal stress is associated with long-term disturbances in HPA axis function. Moreover, prenatal stress in animals is linked with anxiety in later life. Likewise, in humans, gestational stress has a significant impact on emotional problems of the offspring. However, to date, there have been no studies investigating the effects of prenatal glucocorticoid exposure on psychological, endocrine, and autonomic responses to a standardized psychosocial stress test in children aged 10 years. Furthermore, studies investigating the effects of prenatal glucocorticoids on anxiety in children aged 10 years as assessed by self-report as well as maternal and paternal rating are lacking. In particular, knowledge is lacking about healthy children born after the 34th week of gestation without complications (e.g. oxygen administration because of respiratory distress syndrome) as well as with no other physical diseases or disabilities after birth. In addition, to date, the long-term effects of prenatal glucocorticoid exposure in children who are healthy and show no disparities in their level of development are poorly understood. In a cross-sectional study design, a total sample of 135 children was examined. The Glucocorticoids+Tocolytics (GC+TOC) group was characterized by tocolytic treatment of the children's mothers due to signs of preterm labor during the second trimester of pregnancy. In addition, the pregnant women received glucocorticoid treatment (betamethasone) in order to accelerate fetal lung maturation in case of preterm birth. The Tocolytics (TOC) group consisted of children whose mothers also had signs of preterm labor during the second trimester of pregnancy. These mothers, like the mothers of the GC+TOC group, were administered tocolytic treatment, but did not receive glucocorticoid