Principles of Tissue Engineering

INTRODUCTION TO TISSUE ENGINEERING

1. The History and Scope of Tissue Engineering
Joseph P. Vacanti and Charles A. Vacanti

2. The Challenge of Imitating Nature
Robert M. Nerem

3. Moving into the Clinic
Alan J. Russell and Timothy Bertram

4. Future Perspectives
Mark E. Furth and Anthony Atala

PART ONE: THE BASIS OF GROWTH AND DIFFERENTIATION

5. Molecular Biology of the Cell
Jonathan Slack

6. Organization of Cells into Higher-Ordered Structures
Jon D. Ahlstrom and Carol A. Erickson

7. Dynamics of Cell-ECM Interactions
M. Petreaca and Manuela Martins-Green

8. Matrix Molecules and Their Ligands
Bjorn Reino Olsen

9. Morphogenesis and Tissue Engineering
A.H. Reddi

10. Gene Expression, Cell Determination and Differentiation
William Nikovits, Jr. and Frank E. Stockdale

PART TWO: IN VITRO CONTROL OF TISSUE DEVELOPMENT

11. Engineering Functional Tissues
Lisa E. Freed and Farshid Guilak

12. Principles of Tissue Culture and Bioreactor Design
R.I. Freshney, B. Obradovic, W. Grayson, C. Cannizzaro and Gordana Vunjak-Novakovic

13. Regulation of Cell Behavior by Extracellular Proteins
Amy Bradshaw and E. Helene Sage

14. Growth Factors
Thomas F. Deuel and Yunchao Chang

15. Mechanochemical Control of Cell Fate Switching
Donald E. Ingber

PART THREE: IN VIVO SYNTHESIS OF TISSUES AND ORGANS

16. In Vivo Synthesis of Tissues and Organs
Brendan A. Harley and Ioannis V. Yannas


PART FOUR: MODELS FOR TISSUE ENGINEERING

17. Models as Precursors for Prosthetic Devices
Eugene Bell

18. Quantitative Aspects
Alan J. Grodzinsky, Roger D. Kamm, and Douglas A. Lauffenburger

PART FIVE: BIOMATERIALS IN TISSUE ENGINEERING

19. Micro-Scale Patterning of Cells and Their Environment
Xingyu Jiang, Shuichi Takayama, Robert G. Chapman, Ravi S. Kane and George M. Whitesides

20. Cell Interactions with Polymers
W. Mark Saltzman and Themis R. Kyriakides

21. Matrix Effects
Jeffrey A. Hubbell

22.

Robert Lanza is an American scientist and author whose research spans the range of natural science, from biology to theoretical physics. TIME magazine recognized him as one of the "100 Most Influential People in the World,” and Prospect magazine named him one of the Top 50 "World Thinkers.” He has hundreds of scientific publications and over 30 books, including definitive references in the fields of stem cells, tissue engineering, and regenerative medicine. He's a former Fulbright Scholar and studied with polio-pioneer Jonas Salk and Nobel laureates Gerald Edelman (known for his work on the biological basis of consciousness) and Rodney Porter. He also worked closely (and co-authored papers in Science on self-awareness and symbolic communication) with noted Harvard psychologist BF Skinner. Dr. Lanza was part of the team that cloned the world's first human embryo, the first endangered species, and published the first-ever reports of pluripotent stem cell use in humans. Robert Langer received honorary doctorates from the ETH (Switzerland) in 1996 and the Technion (Israel) in 1997. Dr. Langer is the Kenneth J. Germeshausen Professor of Chemical and Biomedical Engineering at MIT. He received a Bachelor's Degree from Cornell University in 1970 and a Sc.D. from MIT in 1974, both in chemical engineering. Dr. Langer has written 590 articles, 400 abstracts, 350 patents, and has edited 12 books.Dr. Langer has received over 70 major awards, including the Gairdner Foundation International Award, the Lemelson-MIT prize, the American Chemical Society (ACS) Polymer Chemistry and Applied Polymer Science Awards, Creative Polymer Chemistry Award (ACS, Polymer Division), the Pearlman Memorial Lectureship Award (ACD, Biochemical Technology Division), and the A.I.Ch.E's Walker, Professional Progress, Bioengineering, and Stine Materials Science and Engineering Awards. In 1989, Dr. Langer was elected to the Institute of Medicine and the National Academy of Sciences, and in 1992 he was