Protein Misfolding, Aggregation and Conformational Diseases

- The pathogenesis of Alzheimer's disease

- Free radicals, metal ions and Ab aggregation and neurotoxicity

- The pathogenesis of Parkinson's disease

- a-Synuclein aggregation and Parkinson's disease

- Cell biology of a-synuclein and PD

- Pathogenesis of prion diseases

- Mamalian prion proteins

- The Yeast prion proteins Sup35p and Ure2p

- Immunoglobulin light chain and systemic AL amyloidosis

- Islet amyloid and type 2 diabetes

- b2-Microglobulin and dialysis-related amyloidosis

- Serum amyloid A and AA amyloidosis

- Transthyretin and familial amyloid polyneuropathy

- Human lysozyme

- Serine proteinase inhibitors (serpins) in pathophysiology

- Human Cu/Zn superoxide dismutase and familial amyotrophic lateral sclerosis

- Understanding the effects of cancer-associated mutations in the tumor suppressor protein p53. Protein aggregation in muscle fibres and respective neuromuscular disorders

- Muscular dystrophies and protein mutations

- The functional consequences of the dystrophin deficiency in skeletal muscles

- The eye lens proteins and cataracts

- Glutamine/asparagine-rich regions in proteins and polyglutamine diseases

- Ataxins and spinocerebellar ataxias

- Molecular pathogenesis of the polyglutamine disease: Spinal and bulbar muscular atrophy

- Nonenzymatic glycation (Maillard reaction) of crystallins and cataracts

- Defective glycosilation and muscular dystrophies