Proteomics in Drug Research
(Sprache: Englisch)
From the skillful handling of proteomic technology to the successful application in target finding and drug discovery - this handbook has all the information that the professional proteomics user needs. Contains numerous contributions by experts from the...
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From the skillful handling of proteomic technology to the successful application in target finding and drug discovery - this handbook has all the information that the professional proteomics user needs. Contains numerous contributions by experts from the pharmaceutical industry and public proteomics consortia.
Klappentext zu „Proteomics in Drug Research “
From skillful handling of the wide range of technologies to successful applications in drug discovery -- this handbook has all the information professional proteomics users need.Edited by experts working at one of the hot spots in European proteomic research, the numerous contributions by experts from the pharmaceutical industry and public proteomics consortia to provide the necessary perspective on current trends and developments in this exciting field.Following an introductory chapter, the book moves on to proteomic technologies, such as protein biochips, protein-protein interactions, and proteome analysis in situ. The section on applications includes bioinformatics, Alzheimer's disease, neuroproteomics, plasma and T-cell proteomics, differential phosphoproteome analysis and biomarkers, as well as pharmacogenomics.Invaluable reading for medicinal and pharmaceutical chemists, gene technologists, molecular biologists, and those working in the pharmaceutical industry.
By delving beyond the genomic information, proteomics can address problems that are inaccessible to conventional genomics studies. These new and powerful analytical techniques open up new possibilities for the investigation of drug action and for the development of new drugs.
From skillful handling of the wide range of technologies to successful applications in drug discovery -- this handbook has all the information professional proteomics users need.
Edited by experts working at one of the hot spots in European proteomic research, the numerous contributions by experts from the pharmaceutical industry and public proteomics consortia to provide the necessary perspective on current trends and developments in this exciting field.
Following an introductory chapter, the book moves on to proteomic technologies, such as protein biochips, protein-protein interactions, and proteome analysis in situ. The section on applications includes bioinformatics, Alzheimer's disease, neuroproteomics, plasma and T-cell proteomics, differential phosphoproteome analysis and biomarkers, as well as pharmacogenomics.
With its coverage of a wide range of technologies and areas of application, this book is invaluable for medicinal and pharmaceutical chemists, gene technologists, molecular biologists, and those working in the pharmaceutical industry.
From skillful handling of the wide range of technologies to successful applications in drug discovery -- this handbook has all the information professional proteomics users need.
Edited by experts working at one of the hot spots in European proteomic research, the numerous contributions by experts from the pharmaceutical industry and public proteomics consortia to provide the necessary perspective on current trends and developments in this exciting field.
Following an introductory chapter, the book moves on to proteomic technologies, such as protein biochips, protein-protein interactions, and proteome analysis in situ. The section on applications includes bioinformatics, Alzheimer's disease, neuroproteomics, plasma and T-cell proteomics, differential phosphoproteome analysis and biomarkers, as well as pharmacogenomics.
With its coverage of a wide range of technologies and areas of application, this book is invaluable for medicinal and pharmaceutical chemists, gene technologists, molecular biologists, and those working in the pharmaceutical industry.
Inhaltsverzeichnis zu „Proteomics in Drug Research “
IntroductionProteomics
Administrative Optimization of consortial proteomic projects
Innovation processes
PROTEOMIC TECHNOLOGIES
Two-dimensional difference gel electrophoresis
HPLC separations in proteomics: strategies and perspectives
Mass spectrometry and quantitative proteomics
Protein biochips in the proteomic field
Current developments for the in-vitro characterization of protein interactions
From target to lead synthesis
The TOPONOME short cut to disease to specific drugs
Proteomic data standardisation, deposition and exchange
APPLICATIONS
Design of proteome-based studies in combination with serology for the identification of biomarkers and novel targets
Proteomics in Alzheimer´s sisease
Clinical neuroproteomics of human body fluids
Peptidomics technologies and applications in drug research
Studies of drug resistance using organelle proteomics
T-Cell
Differential phosphoprotome analysis in human platelets
Proteomics of cardiovascular disease
T-Cell Proteomics
Differential phosphoproteome analysis
Renal Cell Carcinomas
Biomarkers of heart transplant rejection
Pharmacogenomics
Proteome-based studies for the identification of biomarkers and novel targets
(partial contents)
Autoren-Porträt
All six editors are Researchers at the Medical Proteom-Center hosted by the University of Bochum (Germany). This international research center was established in 2002 under the leadership of Helmut E. Meyer, a co-founder of the Protagen AG. Professor Meyer is also initiator and coordinator of the Human Brain Proteome Project within the German National Genome Research Net (NGFN) as well as of the Brain Proteome Project within the Human Proteome Organisation (HUPO BPP).
Bibliographische Angaben
- 2006, XXI, 362 Seiten, 2 farbige Abbildungen, 67 Schwarz-Weiß-Abbildungen, Maße: 17,7 x 25 cm, Gebunden, Englisch
- Herausgegeben: Michael Hamacher, Katrin Marcus, Kai Stühler
- Verlag: Wiley-VCH
- ISBN-10: 3527312269
- ISBN-13: 9783527312269
- Erscheinungsdatum: 20.02.2006
Sprache:
Englisch
Rezension zu „Proteomics in Drug Research “
"Zahlreiche Beiträge von Experten aus der pharmazeutischen Industrie und wissenschaftlichen Proteomics-Zentren vermitteln dem Leser in diesem Band einen Eindruck von den gegenwärtigen Entwicklungen und Perspektiven auf diesem hochinteressanten Gebiet. ... Erwähnenswert ist die große Anzahl von Literaturzitaten, ... enthält dieses Handbuch alle Informationen, die ein professioneller Proteomics-Anwender braucht und ist damit für pharmazeutische und medizinische Chemiker, sowie Molekularbiologen und Gentechnologen von großem Wert." Pharmazie in unserer Zeit
Pressezitat
"The scope is broad, encompassing administrative, scientific, and marketing components....this book can certainly find a place in the library of any organization that makes use of proteomics." ( Journal of Medicinal Chemistry , December 14, 2006)
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