Rakotomalala, L: Hepatitis B virus X protein, and polyploidy
(Sprache: Englisch)
Hepatitis B Virus (HBV) X protein (pX) is implicatedby an unknown mechanism inhepatocellular carcinoma (HCC) development,characterized by increased rate ofchromosomal aberrations. Although most patients clearthe infection and developimmunity, chronic...
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Hepatitis B Virus (HBV) X protein (pX) is implicatedby an unknown mechanism inhepatocellular carcinoma (HCC) development,characterized by increased rate ofchromosomal aberrations. Although most patients clearthe infection and developimmunity, chronic infection in 5 to 10% infectedpatients lead to HCC development inthe 4th to 5th decade of life. I demonstrate thattetracycline-regulated pX expressioninduces multipolar spindles and polyploidy (4N DNA).To understand the mechanismof pX-mediated polyploidy, I investigated whether pXpromotes DNA re-replication.Dual-parameter flow cytometry demonstratespX-dependent BrdU incorporation in cellswith 4N DNA. pX also induces expression ofreplication initiation factors Cdc6 andCdtl, while suppressing geminin expression, anegative regulator of re-replication. G2-phase synchronized cells exhibit pX-dependent: i)nuclear Cdc6 and Mcm5 colocalization;ii) absence of nuclear geminin; iii) increased BrdUincorporation; iv) ATRactivation; v) RAD17 and H2AX phosphorylation; andvi) co-localization of -H2AXwith the DNA elongation factor PCNA.
Autoren-Porträt von Lova Rakotomalala
Lova Rakotomalala was born in Nice in 1977. Lova obtained aBachelor in Science from Tulane University and his PhD fromPurdue University. Lova is currently a post-doctoral fellow atPurdue University. He is working on two projects:1) the development of low-cost CD4 counter 2)cervical cancerdetection combining flow cytometry and PCR genotyping.
Bibliographische Angaben
- Autor: Lova Rakotomalala
- 2009, 144 Seiten, Maße: 15,4 x 22,1 cm, Kartoniert (TB), Englisch
- Verlag: VDM Verlag
- ISBN-10: 3639047087
- ISBN-13: 9783639047080
Sprache:
Englisch
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