Conn's Handbook of Models for Human Aging

The Budding and Fission Yeast Model Systems for Aging Biology: Rapid Advancement with New Technologies 31. Podospora anserina: a filamentous fungus with a strong mitochondrial etiology of aging 32. Invertebrates as model organisms for research on aging biology 33. Invertebrate models for the study of the effects of age on neurotransmitter release 34. Impact of Chronic Exercise on Invertebrate Functional Aging 35. The virtues and challenges of multidimensional analyses of whole brains during aging with single cell resolution 36. Rotifers as a Model for the Biology of Aging 37. The Potential of Comparative Biology to Reveal Mechanisms of Aging in Rotifers 38. Hydra, a model system for deciphering the mechanisms of aging and resistance to aging 39. Regeneration and Aging in The Tunicate Ciona intestinalis 40. Honeybee Workers as Models of Aging

IV. Disease models 41. Approaches to the Assessment of Frailty in Animal Models 42. Genotype and sex differences in life expectancy in transgenic AD mice 43. Animal models of vascular cognitive impairment and dementia 44. Alzheimer's Dementia Drug Discovery: Targeting Synaptic Glutamate Uptake 45. A Transgenic Monkey Model of Huntington's Disease 46. Parkinson's Disease in Humans and in Non-Human Primate Aging and Neurotoxin Models 47. Genetic Models of Parkinson's Disease and Their Study in Non-Human Primates 48. Impact of the Aged Brain Environment on Gene Therapy for Parkinson's Disease 49. Cell Therapy for Parkinson's Disease 50. Genetics of progeria and aging 51. Progeria mouse models 52. Models of Hypertension in Aging 53. Osteoporosis and Cardiovascular Disease in the Elderly 54. The role of the tumor microenvironment in pancreatic ductal adenocarcinoma and preclinical models to study it

V. Organ systems 55. Alopecia 56. Experimental Models of human skin aging 57. Muscle deconditioning and aging: experimental models 58. Models of Immune Aging 59. Sex and the aging immune system 60. Rodent Models of Ovarian Failure 61. Role of Sex and Aging in Mucosal Health 62. Leydig Cell Development and Aging in the Brown Norway Rat: Mechanisms and Consequences 63. Models of aging Kidney: Implications on kidney health and disease 64. Age-Associated Changes in Structure and Function of the Aging Human Lung 65. Glucose, insulin and brain aging 66. Pathology of brain aging and animal models of neurodegenerative diseases 67. Leptin and aging in animal models 68. Age-Related Changes to Bone Structure and Quality in Rodent Models

VI. Mechanisms 69. Dielectric properties of biological tissues; variation with age 70. Experimental Models of Tau Aggregation 71. Aging of Human Mesenchymal Stem Cells 72. Helicases and their relevance to aging 73. Genetics of human aging 74. Epigenetics of brain Aging 75. The Circadian Clock and the Aging Process 76. Super DNAging-New insights into DNA integrity, genome stability and telomeres in the oldest old 77. Model of Chaperones in Aging 78. Chaperone-mediated autophagy 79. Resveratrol in Aging and Age-Related Diseases 80. Resveratrol in experimental models and humans

closely with the Belle Isle Aquarium and the Detroit Public Schools Community District to increase the public understanding of how scientists work and the importance and place of science in protecting the environment. Conn, P. MichaelP. Michael Conn is the Senior Vice President for Research and Associate Provost, Texas Tech Health Sciences Center. He is The Robert C. Kimbrough, Professor of Internal Medicine and Cell Biology/Biochemistry. He was previously Director of Research Advocacy and Professor of Physiology and Pharmacology, Cell Biology and Development and Obstetrics and Gynecology at Oregon Health and Science University and Senior Scientist of the Oregon National Primate Research Center (ONPRC). He served for twelve years as Special Assistant to the President and Associate Director of the ONPRC. After receiving a B.S. degree and teaching certification from the University of Michigan (1971), a M.S. from North Carolina State University (1973), and a Ph.D. degree from Baylor College of Medicine (1976), Conn did a fellowship at the NIH, then joined the faculty in the Department of Pharmacology, Duke University Medical Center where he was promoted to Associate Professor in 1982. In 1984, he became Professor and Head of Pharmacology at the University of Iowa College of Medicine, a position he held for eleven years. Conn is known for his research in the area of the cellular and molecular basis of action of gonadotropin releasing hormone action in the pituitary and therapeutic approaches that restore misfolded proteins to function. His work has led to drugs that have benefitted humans and animals. Most recently, he has identified a new class of drugs, pharmacoperones, which act by regulating the intracellular trafficking of receptors, enzymes and ion channels. He has authored or co-authored over 350 publications in this area and written or edited over 200 books, including texts in neurosciences, molecular biology and endocrinology. Conn has served as the editor of many professional journals and book series (Endocrinology, Journal of Clinical Endocrinology and Metabolism, Endocrine, Methods, Progress in Molecular Biology and Translational Science and Contemporary Endocrinology). Conn served on the National Board of Medical Examiners, including two years as chairman of the reproduction and endocrinology committee. The work of his laboratory has been recognized with a MERIT award from the NIH, the J.J. Abel Award of the American Society for Pharmacology and Experimental Therapeutics, the Weitzman, Oppenheimer and Ingbar Awards of the Endocrine Society, the National Science Medal of Mexico (the Miguel Aleman Prize) and the Stevenson Award of Canada. He is the recipient of the Oregon State Award for Discovery, the Media Award of the American College of Neuropsychopharmacology and was named a distinguished Alumnus of Baylor College of Medicine in 2012. Conn is a previous member of Council for the American Society for Cell Biology and the Endocrine Society and is a prior President of the Endocrine Society, during which time he founded the Hormone Foundation and worked with political leadership to heighten the public's awareness of diabetes. Conn's students and fellows have gone on to become leaders in industry and academia. He is an elected member of the Mexican Institute of Medicine and a fellow of the American Association for the Advancement of Science. He is the co-author of The Animal Research War (2008) and many articles for the public and academic community on the value of animal research and the dangers posed by animal extremism. His op/eds have appeared in The Washington Post, The LA Times, The Wall Street Journal, the Des Moines Register, and elsewhere. Conn consults with organizations that are influenced by animal extremism and with universities and companies facing challenges from these groups.