Reaction monitoring by DPPH
M.Pharm. (PharmChem) student Mr. Viraj P. Jatakiya did the project under the guidance of Dr. D.J. Sen & Dr. R.Badmanaban
(Sprache: Englisch)
The project work focuses on the organic reaction monitoring by DPPH on the synthesised eight compounds of two series having variable electronegative atoms X=O/S/NH which have been screened for CNS depression study by synergistic activity by standard drug....
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The project work focuses on the organic reaction monitoring by DPPH on the synthesised eight compounds of two series having variable electronegative atoms X=O/S/NH which have been screened for CNS depression study by synergistic activity by standard drug. This project is a comparison between the SAR study with antioxidant potentiality by DPPH by using logP values with IC50 values with lambda max in UV.The logP value of 4-carboxamido phenyl thio urea (-0.31) is lesser than 2-carboxy phenyl thiourea (1.53) , so the same property arises during potentiality of lmax in UV. The logP value of 4-carboxy phenyl thiourea (0.84) is greater than 2-carboxamido phenyl urea (0.47), so antioxidant potentiality of IC50 value for 2-carboxamido phenyl urea is -661.18 ppm which is more effective than 4-carboxy phenyl thiourea which is 43.79 ppm.
Bibliographische Angaben
- Autoren: Dhrubo Jyoti Sen , Viraj P. Jatakiya , R. Badmanaban
- 2012, Aufl., 80 Seiten, Kartoniert (TB), Englisch
- Verlag: LAP Lambert Academic Publishing
- ISBN-10: 3847325418
- ISBN-13: 9783847325413
Sprache:
Englisch
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