Receptor Antagonist
(Sprache: Englisch)
Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. A receptor antagonist is a type of receptor ligand or drug that does not provoke a biological response itself upon binding to a...
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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. A receptor antagonist is a type of receptor ligand or drug that does not provoke a biological response itself upon binding to a receptor, but blocks or dampens agonist-mediated responses. In pharmacology, antagonists have affinity but no efficacy for their cognate receptors, and binding will disrupt the interaction and inhibit the function of an agonist or inverse agonist at receptors. Antagonists mediate their effects by binding to the active site or to allosteric sites on receptors, or they may interact at unique binding sites not normally involved in the biological regulation of the receptor''s activity. Antagonist activity may be reversible or irreversible depending on the longevity of the antagonist receptor complex, which, in turn, depends on the nature of antagonist receptor binding. The majority of drug antagonists achieve their potency by competing with endogenous ligands or substrates at structurally-defined binding sites on receptors.
Bibliographische Angaben
- 2010, 104 Seiten, Maße: 22 cm, Kartoniert (TB), Englisch
- Herausgegeben von Surhone, Lambert M.; Tennoe, Mariam T.; Henssonow, Susan F.
- Verlag: Betascript Publishing
- ISBN-10: 6131009236
- ISBN-13: 9786131009235
Sprache:
Englisch
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