Review of QSAR Models for Ready Biodegradation
Manuela Pavan and Andrew P. Worth
(Sprache: Englisch)
Many regulatory laws resulting from the enactment of the United Nations Stockholm Convention in May 2004, together with the new REACH legislation, have promoted significant new activity in the assessment of Persistent, Bioaccumulative and Toxic (PBT)...
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Many regulatory laws resulting from the enactment of the United Nations Stockholm Convention in May 2004, together with the new REACH legislation, have promoted significant new activity in the assessment of Persistent, Bioaccumulative and Toxic (PBT) substances. These are chemicals that have the potential to persist in the environment, accumulate within the tissues of living organisms and, in the case of chemicals categorised as PBTs, show adverse effects following long-term exposure. Under REACH, estimated data generated by (Q)SARs may be used both as a substitute for experimental data, and as a supplement to experimental data in weight-of-evidence approaches. It is foreseen that (Q)SARs will be used for the three main regulatory goals of hazard assessment, risk assessment and PBT/vPvB assessment. In the Registration process under REACH, the registrant will be able to use (Q)SAR data in the registration dossier, provided that adequate documentation is given to argue for the validity of the model(s) used.
Bibliographische Angaben
- Autor: Joint Research Centre
- 2011, 96 Seiten, Kartoniert (TB), Englisch
- Herausgegeben von Commission, European
- Verlag: Dictus Publishing
- ISBN-10: 3844365680
- ISBN-13: 9783844365689
Sprache:
Englisch
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