Selective Heat Sensitivity of Cancer Cells

1. Introduction.- 2. Biochemical Aspects of Heat Sensitivity of Tumour Cells.- 1. Introduction.- 2. Selectivity of the Lethal Effect of Supranormal Temperatures on Tumour Cells.- 3. Nature of the Lesions Caused by Supranormal Temperatures in Mammalian Cells.- 4. Thermal Sensitivity and the Cell Cycle.- 5. Possible Molecular Mechanism(s) of the Heat-Induced Cell Damage.- 3. Actions of Hyperthermia on Tumour Cells Cultured in vitro.- 4. The Effects of Hyperthermia in Animal Tumour Systems.- 1. Introduction.- 2. Animal Tumour Models.- 3. Current Approches.- 4. The Effects of Heat on Animal Tumours.- 5. Hazards and Potentiators of Hyperthermia in the Treatment of Cancer.- 6. Discussion.- 7. Implications of Current Results for Human Therapy.- 8. Summary and Perspectives.- 5. Hyperthermic Treatment of Tumours: Experimental and Clinical Applications.- 1. Introduction.- 2. Experimental Studies.- 3. Clinical Application.- 4. Technique.- 5. Case Report.- 6. Discussion.- 6. Whole-Body Hyperthermia. A Systemic Treatment for Disseminated Cancer.- 1. Methods of Inducing Hyperthermia.- 2. Anaesthesia During Hyperthermia.- 3. Method.- 4. Haemodynamic Response.- 5. Biochemical and Haemotological Changes.- 6. Clinical Results.- 7. Assessment of Response.- 8. Hyperthermia Alone.- 9. Case Reports.- 10. Hyperthermia in Combination with Cytotoxic Drugs.- 11. Case Reports.- 12. Hyperthermia Combined with Local Radiotherapy.- 13. Complications.- 14. Fractionation of Hyperthermia.- 15. Future Management.- 16. Summary.- 7. Hyperthermic Perfusion of Extremities for Melanoma and soft Tissue Sarcomas.- 1. Introduction.- 2. Melanomas.- 3. Discussion.- 4. Conclusions.- 5. Sarcomas.- 6. Results.- 7. Discussion.- 8. Conclusions.