Simultaneous Estimation of Cefixime and Linezolid
By HPLC Method
(Sprache: Englisch)
Development and validation of simple, precise, accurate, economical and sensitive HPLC assay method for the estimation of Cefixime and Linezolid in tablet dosage form. A chromatographic separation was achieved with a Hypersil BDS C18 (250mm,4.6mm ,5µm)...
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Development and validation of simple, precise, accurate, economical and sensitive HPLC assay method for the estimation of Cefixime and Linezolid in tablet dosage form. A chromatographic separation was achieved with a Hypersil BDS C18 (250mm,4.6mm ,5µm) analytical column. A Mixture of Phosphate Buffer (3.0 pH): methanol (40:60, v/v) was used as the mobile phase, at a flow rate of 1.0 ml/min and detector wavelength at 277 nm. The retention time of Cefixime and linezolid was found to be 3.76 and 6.55 min respectively. Theoretical plates was 6896 and 4626 respectively and Tailing factor was 1.32 and 1.28. The linear ranges was 5-15 for cefixime and 15-45 mig/ml for linezolid, and the correlation coefficient was 0.999 for both drugs. The relative standard deviation was found to be less than 2%. A simple, precise, accurate, economical and sensitive HPLC assay method have been developed and validated for the estimation of Cefixime and linezolid in tablet dosage form. All method validation parameters lie within its acceptance crieteria as per ICH Q2(R1) guideline.
Autoren-Porträt von Imran Chaki, Pratik Patel, Naisarg Pujara
Chaki, ImranImran A. Chaki, Master of Pharmacy, Pharmaceutical Quality Assurance from Gujarat Technological University. Research Associate at Quantys Clinical Private Limited in Quality Assurance Department
Bibliographische Angaben
- Autoren: Imran Chaki , Pratik Patel , Naisarg Pujara
- 2019, 88 Seiten, Maße: 22 cm, Kartoniert (TB), Englisch
- Verlag: LAP Lambert Academic Publishing
- ISBN-10: 6139454751
- ISBN-13: 9786139454754
Sprache:
Englisch
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