Stress Responses in Biology and Medicine

Introduction.

Part I: Stress Proteins: Molecular Stress.

1. New Tricks for an Old Dog: The Evolving World of Hsp70.

2. Heat Shock Factors at a Crossroad between Stress and Development.

3. Extracellular Heat Shock Proteins in Cell Signaling and Immunity.

Part II: Stress and Cellular Functions.

4. Membrane Regulation of the Stress Response from Prokaryotic Models to Mammalian Cells.

5. Temperature Stress: Reacting and Adapting--Lessons from Poikilotherms.

6. Endoplasmic reticulum Stress.

7. Chaperones and Proteases: Guardians of Protein Iintegrity in Eukaryotic Organelles.

8. Oxygen, Hypoxia and Stress.

9. Review on Bacterial Stress Topics.

10. Variation in Stress Responses within a Bacterial Species and the Indirect Costs of Stress Resistance.

Part III: Plant Stress.

11. Molecular Mechanisms of Light Stress of Photosynthesis.

12. The Plant Host-Pathogen Interface: Cell Wall and Membrane Dynamics of Pathogen Induced Responses.

13. Long-Term Acclimation of Plants to Elevated CO2 and Its Interaction with Stresses.

Part IV: Stress at Level of the Organism.

14. Heat Shock Proteins and Protection of the Nervous System.

15. Heavy Metal Ions in Normal Physiology, Toxic Stress and Cytoprotection.

16. Interleukin-1 System in CNS Stress: Seizures, Fever and Neurotrauma.

Part V: Stress in Medicine.

17. Chaperonopathies by Defect, Excess, or Mistake.

18. Heat Shock Proteins in Cancer.

19. Drugging the Cancer Chaperone HSP90: Combinatorial Therapeutic Exploitation of Oncogene Addiction and Tumor Stress.

20. Stress, Heat Shock Proteins, and Autoimmunity: How Immune Responses to Heat Shock Proteins are to be Used for the Control of Chronic Inflammatory Diseases.

21. New Molecular Mechanisms of Duodenal Ulceration.

22. Metabolic Syndrome: Psychosocial, Neuroendocrine and Classical Risk Factors in Type 2 Diabetes.

23. Stress Sensitization in Schizophrenia.

Part VI: Psychosocial Stress.

24.

Peter Csermely, born 1958, is a professor of the Semmelweis University (Budapest, Hungary). As a Fogarty Fellow he spent two years in the Joslin Diabetes Center (Harvard University, Boston USA) in 1989-91. His major fields of study are molecular chaperones and networks. As the chairman of the all-European COST network on "Diabetes, Aging and Obesity" he promotes international cooperation in these fields since 1994. In 1995 dr. Csermely launched a highly successful initiative, which provides research opportunities for more than 7000 gifted high school students. He has published five books and more than 160 research papers with a total citation over 1500. Dr. Csermely is the secretary of the Hungarian Biochemical Society, is the founding secretary and president-elect of Cell Stress Society International, is an Ashoka Fellow, was a Fogarty and Howard Hughes Scholar and received several other national and international honors and awards including the 2003 Science Communication Award of the European Molecular Biology Organization, the 2004 Hungarian Science Communication Award and the 2004 Descartes Award of the European Union for Science Communication.