Synthesis and Biological Evaluation of Some New Oxadiazole Analogues
(Sprache: Englisch)
Many commonly used antibiotics are becoming less effective against infections due to the emergence of microbial resistanceIn case of infection, there is an occurrence of increasing fungal infection from day to day. These fungal infections continue to grow...
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Many commonly used antibiotics are becoming less effective against infections due to the emergence of microbial resistanceIn case of infection, there is an occurrence of increasing fungal infection from day to day. These fungal infections continue to grow rapidly. Present antifungal agents do not satisfy the medical need.So, antimicrobial agents are of interest for most researchers. Heterocyclic compounds like 1, 3, 4-oxadiazole, quinazoline and dihydropyrimidone nucleus possess a diversity of biological activity. 1, 3, 4-oxadiazole chemistry with a broad spectrum of medicinal value has got much significance in recent years.Compound4-(4-oxo-2-phenyl-quinazoline-3(4H)-yl)-benzohydrazide 3 on cyclization with different aromatic acids in the presence of phosphoryl chloride (POCl3) give different 1, 3, 4-oxadiazole derivatives. Similarly, compound 3 on reaction with carbon disulphide (CS2) gives substituted oxadiazole thione which on reaction with different halides in the presence ofdimethylformamide (DMF) give oxadiazole thiones analogs 6a-6c. Structural assignments of these compounds have been made by elemental analysis, UV, IR, 1H NMR, and mass spectral data.
Autoren-Porträt von Vivek Kulkarni, Senthil Kumar G P
Kulkarni, VivekHe has completed B Pharm with first class from Shivaji University, Kolhapur and completed M Pharm in Pharmaceutical Chemistry from Bharathi College of Pharmacy, Bharathinagara, RGUHS, Karnataka. At present he is working as Asst professor in department of Pharmaceutical Chemistry at Indira Institute of Pharmacy, Sadavali, Maharashtra.
Bibliographische Angaben
- Autoren: Vivek Kulkarni , Senthil Kumar G P
- 2019, 116 Seiten, Maße: 22 cm, Kartoniert (TB), Englisch
- Verlag: LAP Lambert Academic Publishing
- ISBN-10: 6200211450
- ISBN-13: 9786200211453
Sprache:
Englisch
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