Systems Medicine

PART I: A Road Map Toward Systems Medicine

1. Systems Medicine - Sketching The Landscape

Marc Kirschner

2. Taking Bioinformatics to Systems Medicine

Antoine H.C. Van Kampen and Perry D. Moerland

3. Systems Medicine: The Future of Medical Genomics, Healthcare and Wellness

Mansoor Saqi, Johann Pellet, Irina Roznovat, Alexander Mazein, Stéphane Ballereau, Bertrand Demeulder, and Charles Auffray

4. Next Generation Pathology

Peter Caie amd David Harrison

5. Training in Systems Approaches for the next Generation of Life Scientists and Medical Doctors

Damjana Rozman, Jure Acimovic, and Bernd Schmeck

6. Systems Medicine in Pharmaceutical Research and Development
Lars Kuepfer and Andreas Schuppert

PART II: Opinions and Persepectives

7. Systems Medicine and Infection

Ruth Bowness

8. Systems Medicine for Lung Diseases - Phenotypes and Precision Medicine in Cancer, Infection and Allergy

Bernd Schmeck, Wilhelm Bertrams, Xin Lai, and Julio Vera

9. Third-Kind Encounters In Biomedicine: Immunology Meets Mathematics and Informatics to Become Quantitative and Predictive

Martin Eberhardt, Xin Lai, Namrata Tomar, Shailendra Gupta, Bernd Schmeck, Alexander Steinkasserer, Gerold Schuler, and Julio Vera

10.  Systems Medicine In Oncology: Signaling-Networks Modeling and New Generation Decision-Support Systems

Silvio Parodi, Giuseppe Riccardi, Nicoletta Castagnino, Lorenzo Tortolina, Massimo Maffei, Gabriele Zoppoli, Alessio Nencioni, Alberto Ballestrero, and Franco Patrone

11.  Neurological Diseases from a Systems Medicine Point of View

Marek Ostaszewski, Alexander Skupin, and Rudi Balling

PART III: Systems Medicine Projects and Case Studies

12.  Computational Modeling of Human Metabolism and its Application to