The Ambivalence of Cytostatic Therapy

I. Tumor Induction by Cytostatics?.- The Carcinogenic Properties of Some of the Principal Drugs Used in Clinical Cancer Chemotherapy.- Experimental Investigations with Anti-Cancer Drugs for Carcinogenicity with Special Reference to Immunedepression.- Tests for Tumor Induction by Antitumor Agents.- Adverse Reactions to Cytostatic Agents.- The Changing Pattern of Hodgkin's Disease Seen at Autopsy.- Tumor Inductions by Cytostatics in Man.- Methodological Problems in the Quantitative Assessment of Carcinogenesis in Long-Term Studies.- Summary.- II Tumor Induction by Immunodeficiency?.- Immune Suppression and Chemical Carcinogenesis.- Experimental Investigations on Immunodepressive Properties of Carcinogenic Substances in Male Sprague-Dawley Rats.- The Significance of Immunosuppression and Antigenic Stimulation in the Development of Malignant Lymphomas.- Malignant Disease in Immunodeficient States in Man.- The Effect of Cytostatic Therapy on Cellular Immunity in vitro.- The Balance ofHost Immunocompetence in Chemical Carcinogenesis and "Nonspecific" Immunotherapy.- Tumor Induction in Immunologically Privileged Sites.- Patterns of Neoplastic and Nonneoplastic Diseases of Praomys (Mastomys) Natalensis.- Summary.- III. Cell Synchronization in Tumor Therapy.- The Cell Cycle in Cancer Chemotherapy.- Proliferative Parameters Relevant to Cancer Therapy.- Different Types of DNA-Synthesis and Their Importance in Cancer Growth and Therapy.- Investigations on Partial Synchronization in Ascites Tumors of Different Ploidy and in Solid Transplantable Tumors.- Critical Survey of Experimental Data on in vivo Synchronization by Hydroxyurea.- Cell Synchronization in Solid Tumors.- Experimental and Clinical Results of Chemotherapy after Partial Synchronization of Cell Proliferation.- Problems in the Treatment of Slow-Growing Tumors.- Summary.