The cotransporter NaPi-IIa: enzyme-dependent activity regulation
Cellular mechanisms and health effects
(Sprache: Englisch)
The sodium-coupled phosphate transporter NaPi-IIa is the main cellular carrier accomplishing kidney phosphate reabsorption. It is driven by the electrochemical Na+ gradient across the apical cell membrane, which is maintained by Na+ extrusion across the...
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The sodium-coupled phosphate transporter NaPi-IIa is the main cellular carrier accomplishing kidney phosphate reabsorption. It is driven by the electrochemical Na+ gradient across the apical cell membrane, which is maintained by Na+ extrusion across the basolateral cell membrane through the Na+/K+ ATPase. Energy starvation is sensed by the AMPK, a serine/threonine kinase stimulating several cellular mechanisms increasing energy production and limiting energy consumption. AMPK provides a critical link between energy metabolism and cellular transport. The aging suppressor Klotho, a transmembrane protein, is a protease and hormone has been shown to exert a profound effect on phosphate metabolism, aging, and lifespan. Additionally, the enzymes SGK1, mTOR, Akt/PKB and Nedd4-2 are of critical importance for a wide variety of functions including bone mineralization and energy metabolism. The present book explores the mechanisms of phosphate homeostasis and the role of AMPK, Klotho, SGK1, mTOR, Akt/PKB and Nedd4-2 in the regulation of NaPi-IIa activity.
Autoren-Porträt von Miribane Dërmaku-Sopjani, Mentor Sopjani
Dërmaku-Sopjani, MiribaneDr.sc. Miribane Dërmaku-Sopjani is a chemist and an expert in molecular biochemistry and organic chemistry. Prof. Mentor Sopjani Dr.rer.nat. is a biologist and an expert in molecular cell biology, biochemistry and molecular physiology. Their main research interest is defining the molecular mechanisms of intracellular signaling molecules.
Bibliographische Angaben
- Autoren: Miribane Dërmaku-Sopjani , Mentor Sopjani
- 2019, 120 Seiten, Maße: 22 cm, Kartoniert (TB), Englisch
- Verlag: LAP Lambert Academic Publishing
- ISBN-10: 6139457777
- ISBN-13: 9786139457779
Sprache:
Englisch
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