The Liver

List of Contributors
Preface
Acknowledgements
PART ONE INTRODUCTION
1 Organizational Principles of the Liver
Joe W. Grisham
2 Embryonic Development of the Liver
Roque Bort and Kenneth S. Zaret
PART TWO THE CELLS
3 Microtubules, Actin Filaments and Motor-mediated VesicularTransport
Ronald R. Marchelletta and Sarah F. Hamm-Alvarez
4 Molecular Motors
Peter Satir
5 Ion Pumps and Molecular Motors: P-, F-, and V-typeATPases
Sarah Bond, Daniel J. Cipriano, and Michael Forgac
6 Hepatocyte Surface Polarity: Its Dynamic Maintenance andEstablishment
Lelita T. Braiterman and Ann L. Hubbard
7 Endocytosis as an Essential Process in Liver Function andPathology
Barbara Schroeder and Mark McNiven
8 Membrane Transport in Hepatocellular Secretion
Susan Chi and Mark McNiven
9 Mitochondria
Kastuei Mitra
10 Nuclear Pore Complex
Joseph S. Glavy
11 Protein Maturation and Processing at the EndoplasmicReticulum
Ramanujan S. Hegde
12 Protein Degradation and the Lysosomal System
Susmita Kaushik and Ana Maria Cuervo
13 Peroxisome Assembly, Degradation, and Disease
Peter K. Kim
14 Gap and Tight Junctions in Liver: Composition, Regulation,and Function
Takashi Kojima, Norimasa Sawada, Hiroshi Yamaguchi, Alfredo G.Fort, and David C. Spray
SECTION A HEPATOCYTE
15 Copper Metabolism and the Liver
Michael L. Schilsky and Dennis J. Thiele
16 The Central Role of the Liver in Iron Storage andRegulation of Systemic Iron Homeostasis
Tracey A. Rouault, Victor Gordeuk, and Gregory Anderson
17 Disorders of Bilirubin Metabolism
Namita Roy Chowdhury and Jayanta Roy Chowdhury
GH4. 21. The porphyrias Peter N. Meissner, Richard J. Hift, Ralph E. Kirsch
18 Hepatic fatty acid metabolism and dysfunction
David L. Silver
19 Lipoprotein Metabolism and Cholesterol Balance
David E. Cohen
SECTION B BILE SECRETION
20 Bile Acids and the Enterohepatic Circulation
Alan F. Hofmann
21 Hepatocyte Basolateral Membrane Organic AnionTransporters
Jo. H. Choi, John W. Murray, and Allan

Editor:
Irwin Arias, MD, National Institutes of Health, Bethesda,Maryland. Professor of Physiology, Emeritus, Tufts UniversitySchool of Medicine, Boston, Mass. Visiting Professor ofMedicine, Albert Einstein College of Medicine, Bronx, NY.

Associate editors:

James L. Boyer, Yale University School of Medicine, New Haven,CT, USA

David Shafritz, Albert Einstein College of Medicine, Bronx, NY,USA

Nelson Fausto, Professor and Chair, Department of Pathology,University of Washington, Seattle, WA, USA.

Harvey Alter, Department of Transfusion Medicine, NationalInstitutes of Health, Bethesda, Maryland, USA

David E. Cohen,.Division of Gastroenterology, Brigham andWomen s Hospital, Boston, Massachusetts, USA

Allan Wolkoff, Albert Einstein College of Medicine, Bronx, NY,USA

"Who is the targeted audience for this book? This book "anchors"clinical observations on basic sciences and provides clinicalsignificance to basic science; therefore, I recommend it to allclinicians and researchers who from a clinical or basic standpointwant to understand what the liver does under normal and abnormalcircumstances ... The reader will find the disbursement worthwhileand the time invested in consulting it rewarding."(Gastroenterological, 1 March 2011)