The Molecular Basis of Cell Cycle and Growth Control
(Sprache: Englisch)
Recent advances in our understanding of the biochemical and molecular mechanisms of cell growth and control have led to sensational breakthroughs in the diagnosis and treatment of proliferative and neoplastic diseases. As a consequence, cell growth and...
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Klappentext zu „The Molecular Basis of Cell Cycle and Growth Control “
Recent advances in our understanding of the biochemical and molecular mechanisms of cell growth and control have led to sensational breakthroughs in the diagnosis and treatment of proliferative and neoplastic diseases. As a consequence, cell growth and regulation has become a subject of vital interest to basic researchers and clinicians alike. Never has the need for authoritative reviews such as this been greater.Comprising contributions by an international team of scientists at the forefront of one of today's liveliest areas of biomedical research, this book reports on the state-of-the-science in cell growth and regulation from the conceptual, experimental, and clinical perspective. Written at a level that will appeal to professionals as well as graduate and medical students, it explores a wide range of related topics, with an emphasis on the identification of checkpoints and restriction points and the mechanisms of proliferation competency and cell cycle progression, including: DNA replication and S phase - Mitosis and meiosis - Gene expression and gene regulatory mechanisms - Signal transduction and integration of regulatory information - Differentiation, development, and programmed cell death - Cellular senescence and immortalization.
Inhaltsverzeichnis zu „The Molecular Basis of Cell Cycle and Growth Control “
Preface.Contributors.
PART I.
1. Cell Fates (Arthur B. Pardee).
2. Architectural Organization of the Regulatory Machinery for Transcription, Replication and Repair: Dynamic Temporal-Spatial Parameters of Cell Cycle Control ( Corey D. Braastad, et al.).
PART II.
3. Cell Cycle Regulatory Cascades ( Heide L. Ford, et al.).
4. Membrane Receptors and Signal Transduction Pathways in G1: Regulation of Liver Regeneration and T Cell Proliferation (Joseph F. Porter and David T. Denhardt).
5. Onset of DNA Synthesis and S Phase ( G. Prem-Veer Reddy, et al.).
6. The Progression and Regulation of Mitotic Events (Greenfield Sluder, et al.).7. Cell Cycle Inhibitory Proteins (Carmen Carneiro and Andrew Koff).
8. Chromatin Remodeling and Cancer (Cynthia J. Guidi and Anthony N. Imbalzano).
9. Extracellular Matrix: Tissue Specific Regulator of Cell Proliferation (Aylin Rizki and Mina J. Bissell).
10. Not yet arrived (Judah Folkman).
11. Regulation of Cell Growth, Differentiation, and Death During Metamorphosis (Hans Laufer and Eric H. Baehrecke).
12. Translational Control and the Cell Cycle (Robert E. Rhoads).
PART III.
13. Not yet arrived (Thea Tlsty).
14. Immortalisation by SV40 Large T Antigen (Rowena L. Martinet, et al.).
15. Apoptosis Signaling in Normal and Cancer Cells (Shulin Wang and Wafik S. El-Deiry).
PART IV.
16. Mutagenesis, Mutations, and DNA Repair (Roger D. Johnson).
17. Oncogenes (Stacey J. Baker and E. Premkumar Reddy).
18. Role of the Retinoblastoma Family in Cell Cycle Progression and Growth Control (Valeria Masciullo and Antonio Giordano).
19. p53 Tumor-Suppressor Genes (Faith A. Zamamiri-Davis and Gerard P. Zambetti).
PART V.
20. Cell Cycle and Growth Control: Current Clinical Applications (Michael Deininger).
PART VI.
21. Misregulated Fate--Cancer (Arthur B. Pardee).
Index.
Bibliographische Angaben
- 2004, 2. Aufl., 816 Seiten, Maße: 25,8 cm, Gebunden, Englisch
- Ed. by Gary S. Stein, Arthur B. Pardee et al.
- Verlag: Wiley & Sons
- ISBN-10: 0471250716
- ISBN-13: 9780471250715
Sprache:
Englisch
Rezension zu „The Molecular Basis of Cell Cycle and Growth Control “
"...the book provides a wealth of information and it will be a valuable reference guide for researchers studying mechanisms of normal and aberrant cell growth." (Doody's Electronic Journal)
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