The p2x7 Purinergic Receptor and Mycobacterial Infections in Humans
The role of loss-of-function polymorphisms in the gene for the p2X7 purinergic receptor and mycobacterial infections in humans
(Sprache: Englisch)
Tuberculosis (TB) remains an enormous global health problem. The majority of people infected with Mycobacterium tuberculosis are able to contain their infection, however, in approximately 10% of individuals, active disease eventually develops, usually from...
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Tuberculosis (TB) remains an enormous global health problem. The majority of people infected with Mycobacterium tuberculosis are able to contain their infection, however, in approximately 10% of individuals, active disease eventually develops, usually from reactivation of latent infection. HIV coinfection and other environmental causes of reduced T cell immunity predispose to this progression in a proportion of individuals.There is emerging evidence that genetic variation also influences susceptibility to TB. Activation of the P2X7 receptor kills mycobacteria within macrophages. Several polymorphisms in the P2X7 gene impair this killing. The most common of these polymorphisms was strongly associated with extrapulmonary TB in two separate cohorts in a Sydney population. Furthermore, ATP-mediated killing of mycobacteria was significantly impaired in macrophages from heterozygous subjects and ablated in macrophages from subjects homozygous for this polymorphism. By contrast, noloss-of-function polymorphism was associated with clinical leprosy in a Nepali population. P2X7-mediated killing of mycobacteria can be augmented with stimulation of certain cytokines.
Autoren-Porträt von Suran Fernando
Suran Fernando is a Clinical Immunologist at Royal NorthShore Hospital in Sydney, Australia. He obtained his Medical Degreein 1994 and then attained fellowships of the Royal AustralasianColleges of Physicians and Pathologists in 2001. As an NH&MRCscholar, he completed his doctoral thesis in the MycobacterialLaboratory, Centenary Institute, Sydney in 2006
Bibliographische Angaben
- Autor: Suran Fernando
- 2008, 272 Seiten, Maße: 15 x 22 cm, Kartoniert (TB), Englisch
- Verlag: VDM Verlag Dr. Müller e.K.
- ISBN-10: 3639012267
- ISBN-13: 9783639012262
Sprache:
Englisch
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