Transporters as Drug Carriers
Structure, Function, Substrates
(Sprache: Englisch)
This reference handbook is the first to provide a comprehensive overview, systematically characterizing all known transporters involved in drug elimination and resistance. Combining recent knowledge on all known classes of drug carriers, from microbes to...
Leider schon ausverkauft
versandkostenfrei
Buch (Gebunden)
215.00 €
107 DeutschlandCard Punkte
sammeln
- Lastschrift, Kreditkarte, Paypal, Rechnung
- Kostenlose Rücksendung
- Ratenzahlung möglich
Produktdetails
Produktinformationen zu „Transporters as Drug Carriers “
Klappentext zu „Transporters as Drug Carriers “
This reference handbook is the first to provide a comprehensive overview, systematically characterizing all known transporters involved in drug elimination and resistance. Combining recent knowledge on all known classes of drug carriers, from microbes to man, it begins with a look at human and mammalian transporters. This is followed by microbial, fungal and parasitic transporters with special attention given to transport across those physiological barriers relevant for drug uptake, distribution and excretion.As a result, this key resource lays the foundations for understanding and investigating the molecular mechanisms for multidrug resistance in cancer cells, microbial resistance to antibiotics and pharmacokinetics in general. For anyone working with antibiotics and cancer chemotherapeutics, as well as being of prime interest to biochemists and biophysicists.
Inhaltsverzeichnis zu „Transporters as Drug Carriers “
PART 1 1 The ABC Transporters: Structural Insights into Drug Transport2 Biochemistry, Physiology, and Pharmacology of Nucleoside and Nucleobase Transporters3 Organic Anion Transporting Polypeptides (Oatps/OATPs)4 CNS Transporters as Drug TargetsPART 2 5 Bacterial Multidrug Transporters: Molecular and Clinical Aspects6 Pleiotropic drug resistance in yeast and fungal pathogensPART 3 7 QSAR studies on ABC-transporters: how to deal with polyspecificity8 Drug Transporter PharmacophoresPART 4 9 Biological Membranes and Drug Transport10 Transport at the Blood-Brain Barrier11 Bile canalicular transporters 12 Interplay of Cytochrome P450 Isoenzymes and ABC-transporter13 ABC-Transporter: From target to antitargetPART 3 14 A Systems Biology View of Drug Transporters15 Drug Transporters in Health and Disease
Autoren-Porträt
Gerhard Ecker is the head of the Pharmacoinformatics Initiative at the Department of Medicinal Chemistry, University of Vienna. He studied Pharmacy at the University of Vienna (Ph.D. thesis advisors: W. Fleischhacker and C.R. Noe) and did post-doctoral work with J. Seydel in Borstel (Germany) where he started his SAR and QSAR studies on P-glycoprotein. His main scientific interests are pharmacoinformatic approaches to target drug efflux pumps, in silico screening methods for promiscuous targets, and non-linear methods in drug design.Peter Chiba is a senior scientist and lecturer at the Medical University of Vienna. He holds a doctorate in Medicine from the University of Vienna and worked at the Universities of Nijmegen (The Netherlands) and South Florida (USA) as a Fulbright scholar and post-doctoral associate. His research focuses on multidrug transport and resistance to drugs in treatment of cancer and microbial disease.
Bibliographische Angaben
- 2009, XX, 429 Seiten, 10 farbige Abbildungen, Maße: 17,9 x 24,8 cm, Gebunden, Englisch
- Herausgegeben: Gerhard Ecker, Peter Chiba, Raimund Mannhold
- Verlag: Wiley-VCH
- ISBN-10: 3527316612
- ISBN-13: 9783527316618
- Erscheinungsdatum: 14.10.2009
Sprache:
Englisch
Rezension zu „Transporters as Drug Carriers “
"Overall, the book is well organized and the topics are clearly and easily accessible. This book offers many strengths ...but overall is quite worthwhile." (ChemMedChem, January 2011) "Overall, the book is a specialised text (as reflected in the price) that provides a comprehensive review of drug transporters. It would also be a welcome addition to any well stocked university library." (PJ Online, 12 November 2010)
Pressezitat
"Overall, the book is well organized and the topics are clearly and easily accessible. This book offers many strengths ...but overall is quite worthwhile." ( ChemMedChem , January 2011)"Overall, the book is a specialised text (as reflected in the price) that provides a comprehensive review of drug transporters. It would also be a welcome addition to any well stocked university library." (PJ Online, 12 November 2010)
Kommentar zu "Transporters as Drug Carriers"
0 Gebrauchte Artikel zu „Transporters as Drug Carriers“
| Zustand | Preis | Porto | Zahlung | Verkäufer | Rating |
|---|
Schreiben Sie einen Kommentar zu "Transporters as Drug Carriers".
Kommentar verfassen