Vitamin D, 2 Vols.
(Sprache: Englisch)
Vitamin D, a steroid hormone, has mainly been known for its effects on bone and osteoporosis. The current therapeutic practices expand into such markets as cancer research, pediatrics, nephrology, dermatology, immunology, and genetics. This edition includes...
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Vitamin D, a steroid hormone, has mainly been known for its effects on bone and osteoporosis. The current therapeutic practices expand into such markets as cancer research, pediatrics, nephrology, dermatology, immunology, and genetics. This edition includes more than 100 chapters covering everything from chemistry and metabolism to mechanisms of action, diagnosis and management, new analogs, and emerging therapies.
Klappentext zu „Vitamin D, 2 Vols. “
Vitamin D, a steroid hormone, has mainly been known for its effects on bone and osteoporosis. The current therapeutic practices expand into such markets as cancer research, pediatrics, nephrology, dermatology, immunology, and genetics. This 3e includes over 100 chapters covering everything from chemistry and metabolism to mechanisms of action, diagnosis and management, new analogs, and emerging therapies. This complete reference works is a must-have resource for anyone working in endocrinology, osteology, bone biology, or cancer research.Most comprehensive, up-to-date two-volume set on Vitamin D
Initial chapters cover the chemistry and metabolism of vitamin D, role in mineralization, other target organs, and general physiological effects
Second volume is more clinically oriented addressing deficiency problems (including diagnosis, interactions in the endocrine system, and involvement in malignancies)
Further sections on emerging uses for treatments of auto-immune diseases and diabetes
New chapters on squamous cell cancer, brain cancer, thyroid cancer and many more
Over 600 illustrations and figures available on CD
Inhaltsverzeichnis zu „Vitamin D, 2 Vols. “
Section I: Chemistry, Metabolism, Circulation1 Historical Overview of Vitamin D
Hector F. Deluca
2 Photobiology of Vitamin D
Michael F. Holick
3 The Activating Enzymes of Vitamin D Metabolism (25- and 1a-Hydroxylases)
Glenville Jones and David E. Prosser
4 CYP24A1: Structure, Function, and Physiological Role
Rene St. Arnaud
5 The Vitamin D Binding Protein: DBP
Roger Bouillon
6 Industrial Aspects of Vitamin D
Arnold L. Hirsch
Section II: Mechanisms of Action
7 VDR
J. Wesley Pike
8 Nuclear Vitamin D Receptor: Natural Ligands, Molecular Structure-Function, and Transcriptional Control of Vital Genes
Mark R. Haussler, Carol A. Haussler, Jui-Cheng Hsieh, Peter W. Jurutka, and G. Kerr Whitfield
9 Structural Basis for Ligand Activity in VDR
Dino Moras and Natacha Rochel
10 Coregulators of VDR-mediated Gene Expression
Paul McDonald and Diane R. Dowd
11 Target Genes of Vitamin D: Spatio-temporal Interaction of Chromatin, VDR and Response Elements
Carsten Carlberg
12 Epigenetic Modifications in Vitamin D Receptor Mediated Transrepression
Shigeaki Kato, Alexander Kouzmenko, Fumiaki Ohtake, and Ryoji Fujiki
13 Vitamin D and Wnt/ß-Catenin Signaling
Albert Munoz, José Manuel González-Sancho, and María Jesús Larriba
14 Vitamin D Response Element Binding Protein
John S. Adams, Thomas S. Lisse, Hong Chen, Mark S. Nanes, and Martin Hewison
15 Vitamin D Sterol/VDR Conformational Dynamics and Nongenomic Actions
Anthony W. Norman and Mathew T. Mizwicki
Section III: Mineral and Bone Homeostasis
16 Development of the Skeleton
Jane B. Lian, Gary S. Stein, Martin Montecino, Janet L. Stein, Andre J. van Wijnen
17 Vitamin D Regulation of Osteoblast Function
Renny Franchesci and Yan Li
18 Osteoclasts
F. Patrick Ross
19 Molecular Mechanisms for Regulation of Intestinal Calcium and Phosphate Absorption by Vitamin D
James Fleet and Ryan D. Schoch
20 The Calbindins:
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Calbindin-D28K and Calbindin-D9K and the Epithelial Calcium Channels TRPV5 and TRPV6
Sylvia Christakos, Leila Mady, and Puneet Dhawan
21 Mineralization
Adele Boskey and Eve Donnelly
22 VITAMIN D REGULATION OF TYPE I COLLAGEN EXPRESSION IN BONE
Barbara Kream and Alexander Lichtler
23 Target Genes: Bone Proteins
Howard Morris, Paul H. Anderson, Gerald J. Atkins, and David M. Findlay
24 Vitamin D and the Calcium-Sensing Receptor
Edward M. Brown
25 Effects of 1,25-Dihydroxyvitamin D3 on Voltage-Sensitive Calcium Channels in Osteoblast Differentiation and Morphology
Mary Farach-Carson and William R. Thompson
Section IV: Targets (David/John/Wes)
26 Vitamin D and the Kidney
Rajiv Kumar and Peter Tebben
27 Vitamin D and the Parathyroids
Justin Silver and Tally Neveh-Many
28 Cartilage
Barbara D. Boyan, Maryam Doroudi and Zvi Schwartz
29 Vitamin D and Oral Heath
Ariane Berdal, Muriel Molla, Vianney Descroix
30 The Role of Vitamin D and its Receptor in Skin and Hair Follicle Biology
Marie B. Demay
31 Vitamin D and the Cardiovascular System
David Gardner, Songcang Chen, Denis Glenn, and Wei Ni
32 Vitamin D: A Neurosteroid Affecting Brain Development and Function; Implications for Neurological and Psychiatric Disorders
John McGrath, Darryl Eyles, and Thomas Burne
33 Contributions of Genetically Modified Mouse Models to Understanding the Physiology and Pathophysiology of the 25-hydroxyvitamin D-1-alpha Hydroxylase Enzyme [1a(OH)ase] and the Vitamin D Receptor (VDR)
David Goltzman, Geoffrey N. Hendy, and Richard Kremer
Section V: Human Physiology
34 Vitamin D: Role in the Calcium and Phosphorus Economies
Robert P. Heaney
35 Fetus, Neonate and Infant
Chris Kovacs
36 Vitamin D Deficiency and Calcium Absorption During Childhood
Steven A. Abrams
37 Adolescence and Acquisition of Peak Bone Mass
Connie Weaver, Rick Lewis, and Emma Liang
38 Vitamin D Metabolism in Pregnancy and La
Sylvia Christakos, Leila Mady, and Puneet Dhawan
21 Mineralization
Adele Boskey and Eve Donnelly
22 VITAMIN D REGULATION OF TYPE I COLLAGEN EXPRESSION IN BONE
Barbara Kream and Alexander Lichtler
23 Target Genes: Bone Proteins
Howard Morris, Paul H. Anderson, Gerald J. Atkins, and David M. Findlay
24 Vitamin D and the Calcium-Sensing Receptor
Edward M. Brown
25 Effects of 1,25-Dihydroxyvitamin D3 on Voltage-Sensitive Calcium Channels in Osteoblast Differentiation and Morphology
Mary Farach-Carson and William R. Thompson
Section IV: Targets (David/John/Wes)
26 Vitamin D and the Kidney
Rajiv Kumar and Peter Tebben
27 Vitamin D and the Parathyroids
Justin Silver and Tally Neveh-Many
28 Cartilage
Barbara D. Boyan, Maryam Doroudi and Zvi Schwartz
29 Vitamin D and Oral Heath
Ariane Berdal, Muriel Molla, Vianney Descroix
30 The Role of Vitamin D and its Receptor in Skin and Hair Follicle Biology
Marie B. Demay
31 Vitamin D and the Cardiovascular System
David Gardner, Songcang Chen, Denis Glenn, and Wei Ni
32 Vitamin D: A Neurosteroid Affecting Brain Development and Function; Implications for Neurological and Psychiatric Disorders
John McGrath, Darryl Eyles, and Thomas Burne
33 Contributions of Genetically Modified Mouse Models to Understanding the Physiology and Pathophysiology of the 25-hydroxyvitamin D-1-alpha Hydroxylase Enzyme [1a(OH)ase] and the Vitamin D Receptor (VDR)
David Goltzman, Geoffrey N. Hendy, and Richard Kremer
Section V: Human Physiology
34 Vitamin D: Role in the Calcium and Phosphorus Economies
Robert P. Heaney
35 Fetus, Neonate and Infant
Chris Kovacs
36 Vitamin D Deficiency and Calcium Absorption During Childhood
Steven A. Abrams
37 Adolescence and Acquisition of Peak Bone Mass
Connie Weaver, Rick Lewis, and Emma Liang
38 Vitamin D Metabolism in Pregnancy and La
... weniger
Autoren-Porträt von David Feldman
David Feldman, MD, is Emeritus Professor of Medicine (Active) at Stanford University School of Medicine where he has been on the faculty since 1974. He has been a full professor since 1984 and was chief of the Endocrinology Division for 10 years. His laboratory studies the role of steroid hormone receptors, particularly the vitamin D receptor, and its mechanism of action. His current major research focus is hormone-dependent cancer including breast cancer and prostate cancer and the pathways by which vitamin D inhibits cancer growth. Professor Feldman is actively involved in both basic science approaches to the anti-cancer actions of vitamin D as well as to clinical trials studying the use of vitamin D in breast and prostate cancer. Professor Feldman was recently honored with an award for a Career of Outstanding Contributions to Vitamin D Research. He has authored over 290 medical research articles, reviews, editorials, and book chapters. In addition to being a co-editor of all four editions of OSTEOPOROSIS, he is the editor-in-chief of Vitamin D, just published in its third edition.
Bibliographische Angaben
- Autor: David Feldman
- 2011, 3rd ed., 2144 Seiten, Maße: 23,6 x 12,3 cm, Gebunden, Englisch
- Herausgegeben: David Feldman, J. Wesley Pike, John S. Adams
- Verlag: Academic Press
- ISBN-10: 0123819784
- ISBN-13: 9780123819789
- Erscheinungsdatum: 01.09.2011
Sprache:
Englisch
Rezension zu „Vitamin D, 2 Vols. “
"In this brief review, it is impossible to cover all the nuances of vitamin D addressed in this book. Interested readers may want to peruse the book chapters to assess relevance to their personal interests. I regard this impressive text as a "must have" in the medical libraries of most hospitals. Clinicians and researchers with an interest in vitamin D may want their own personal copy for ready reference. I highly recommend it and congratulate the authors and editors in providing a much needed reference text on arguably one of the more important nutrients to our species."--American Journal of Human Biology "In this remarkable compendium, the editors provide a fresh and comprehensive review of a multifaceted and sometimes controversial vitamin D. This third edition is not just an update, but a greatly expanded work organized to authoritatively cover the evidence for new roles of vitamin D in cardiovascular health, immunity, psychiatric disorders, and much more. In more than 100 chapters, experts span the history of vitamin D, update its molecular mechanism and chemistry, provide specifics of clinical use in disorders of the skeleton, and review progress in an array of diseases including diabetes, inflammatory bowel disease, multiple sclerosis, and psoriasis. In this edition one finds new information for a broad audience including internal medicine, nutrition, orthopedics, basic scientists, and teachers. How does one define optimal vitamin D status? How does vitamin D affect innate immunity? What are the epigenetic modifications of the vitamin D receptor that contribute to its function? Are there other natural ligands for the vitamin D receptor? These are a part of the new increased scope of Vitamin D, Third Edition. If you are interested in vitamin D, you should have this book." -Mark S. Nanes, MD, PhD, Professor of Medicine, Emory University, Atlanta, GA, USA "The Third Edition of the classic text Vitamin D is a superb summary of an important and topical issue. Its
... mehr
contributors are truly experts in the field and they have managed to comprehensively describe the biochemistry, pharmacology and effects of vitamin D as well as to eloquently weave in the relevant biology of bone, muscle, immunology and other relevant tissues. The 105 readable chapters offer a complete and well balanced mix of basic and clinical topics that provides an opportunity to understand the full breadth of vitamin D action. Each section represents an excellent summary of up-to-date information and, as a whole, this text offers an outstanding resource that will appeal to a broad spectrum of readers - from students to established clinicians and investigators." -Eric Orwoll, MD, Department of Medicine, Division of Endocrinology, Diabetes, and Clinical Nutrition, Oregon Health and Science University, Portland, OR, USA "The Third Edition of Vitamin D is well written, comprehensive and balanced. Several of the new chapters, such as Epigenetic Modifications and Wnt/ss-Catenin Signaling, have strayed away from the "traditional" vitamin D but the authors have put these topics very clearly into perspective in ways that will be valuable to those studying vitamin D action. The overall list of authors for this book is a virtual '"who's who" of vitamin D research, and the coverage of the topic is appropriately broad, including those matters in nutrition and epidemiology that have been the subject of much interest in recent years." -T. Jack Martin, AO MD DSC FRACP FRCPA FAA FRS, John Holt Fellow, Emeritus Professor of Medicine Bone, Joint & Cancer Unit, St Vincent's Institute, Victoria, Australia
... weniger
Pressezitat
"In this brief review, it is impossible to cover all the nuances of vitamin D addressed in this book. Interested readers may want to peruse the book chapters to assess relevance to their personal interests. I regard this impressive text as a ''must have'' in the medical libraries of most hospitals. Clinicians and researchers with an interest in vitamin D may want their own personal copy for ready reference. I highly recommend it and congratulate the authors and editors in providing a much needed reference text on arguably one of the more important nutrients to our species."-- American Journal of Human Biology"In this remarkable compendium, the editors provide a fresh and comprehensive review of a multifaceted and sometimes controversial vitamin D. This third edition is not just an update, but a greatly expanded work organized to authoritatively cover the evidence for new roles of vitamin D in cardiovascular health, immunity, psychiatric disorders, and much more. In more than 100 chapters, experts span the history of vitamin D, update its molecular mechanism and chemistry, provide specifics of clinical use in disorders of the skeleton, and review progress in an array of diseases including diabetes, inflammatory bowel disease, multiple sclerosis, and psoriasis. In this edition one finds new information for a broad audience including internal medicine, nutrition, orthopedics, basic scientists, and teachers. How does one define optimal vitamin D status? How does vitamin D affect innate immunity? What are the epigenetic modifications of the vitamin D receptor that contribute to its function? Are there other natural ligands for the vitamin D receptor? These are a part of the new increased scope of Vitamin D, Third Edition . If you are interested in vitamin D, you should have this book."
-Mark S. Nanes, MD, PhD, Professor of Medicine, Emory University, Atlanta, GA, USA
"The Third Edition of the classic text Vitamin D is a superb summary of an important and
... mehr
topical issue. Its contributors are truly experts in the field and they have managed to comprehensively describe the biochemistry, pharmacology and effects of vitamin D as well as to eloquently weave in the relevant biology of bone, muscle, immunology and other relevant tissues. The 105 readable chapters offer a complete and well balanced mix of basic and clinical topics that provides an opportunity to understand the full breadth of vitamin D action. Each section represents an excellent summary of up-to-date information and, as a whole, this text offers an outstanding resource that will appeal to a broad spectrum of readers - from students to established clinicians and investigators."
-Eric Orwoll, MD, Department of Medicine, Division of Endocrinology, Diabetes, and Clinical Nutrition, Oregon Health and Science University, Portland, OR, USA
"The Third Edition of Vitamin D is well written, comprehensive and balanced. Several of the new chapters, such as Epigenetic Modifications and Wnt/ß-Catenin Signaling, have strayed away from the "traditional" vitamin D but the authors have put these topics very clearly into perspective in ways that will be valuable to those studying vitamin D action. The overall list of authors for this book is a virtual '"who's who" of vitamin D research, and the coverage of the topic is appropriately broad, including those matters in nutrition and epidemiology that have been the subject of much interest in recent years."
-T. Jack Martin, AO MD DSC FRACP FRCPA FAA FRS, John Holt Fellow, Emeritus Professor of Medicine Bone, Joint & Cancer Unit, St Vincent's Institute, Victoria, Australia
-Eric Orwoll, MD, Department of Medicine, Division of Endocrinology, Diabetes, and Clinical Nutrition, Oregon Health and Science University, Portland, OR, USA
"The Third Edition of Vitamin D is well written, comprehensive and balanced. Several of the new chapters, such as Epigenetic Modifications and Wnt/ß-Catenin Signaling, have strayed away from the "traditional" vitamin D but the authors have put these topics very clearly into perspective in ways that will be valuable to those studying vitamin D action. The overall list of authors for this book is a virtual '"who's who" of vitamin D research, and the coverage of the topic is appropriately broad, including those matters in nutrition and epidemiology that have been the subject of much interest in recent years."
-T. Jack Martin, AO MD DSC FRACP FRCPA FAA FRS, John Holt Fellow, Emeritus Professor of Medicine Bone, Joint & Cancer Unit, St Vincent's Institute, Victoria, Australia
... weniger
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