Vitamin D Analogs in Cancer Prevention and Therapy

1 Molecular Biology of Vitamin D.- Evolution and Function of Vitamin D.- Current Understanding of the Function of the Nuclear Vitamin D Receptor in Response to Its Natural and Synthetic Ligands.- Approaches to Evaluating the Association of Vitamin D Receptor Gene Polymorphisms with Breast Cancer Risk.- Ligand Structure-Function Relationships in the Vitamin D Endocrine System from the Perspective of Drug Development (Including Cancer Treatment).- Antiproliferative Signalling by 1,25(OH)2D3 in Prostate and Breast Cancer Is Suppressed by a Mechanism Involving Histone Deacetylation.- Mechanisms Implicated in the Growth Regulatory Effects of Vitamin D Compounds in Breast Cancer Cells.- Squamous Cell Carcinomas Fail to Respond to the Prodifferentiating Actions of 1,25(OH)2D: Why?.- A Novel Vitamin D-Regulated Immediate-Early Gene, IEX-1, Alters Cellular Growth and Apoptosis.- Extrarenal Sites of Calcitriol Synthesis: The Particular Role of the Skin.- Cultured Rat Growth Plate Chondrocytes Express Low Levels of 1a-Hydroxylase.- Gene Amplification and Splice Variants of 25-Hydroxyvitamin D3 1, ?-Hydroxylase (CYP27B1) in Glioblastoma Multiforme-A Possible Role in Tumor Progression?.- Regulation of the 25-Hydroxyvitamin D-1?-Hydroxylase Gene and Its Splice Variant.- Combination of Vitamin D Metabolites with Selective Inhibitors of Vitamin D Metabolism.- Importance Of Cytochrome P450-Mediated Metabolism in the Mechanism of Action of Vitamin D Analogs.- 2 The Vitamin D System in Cancer.- The Role of Vitamin D in Prostate Cancer.- Vitamin D Autocrine System and Prostate Cancer.- Analysis of the Vitamin D System in Cervical Carcinomas, Breast Cancer and Ovarian Cancer.- Short-Chain Fatty Acids and Colon Cancer Cells: The Vitamin D Receptor-Butyrate Connection.- Analysis of theVitamin D system in Cutaneous Malignancies.- 3 Antitumor Effects of Vitamin D Analogs.- Evaluation of Vitamin D Analogs as Therapeutic Agents for Prostate Cancer.- Design, Synthesis, and Biological Studies