Yamaguchi, M: Role of regucalcin in cell homeostasis

This monograph updates readers with the latest findings in biomedical science relating to 'Regucalcin', a protein discovered by the author in 1978 and which proved to be a highly significant discovery. Regucalcin was later demonstrated to possess a pivotal role in cell regulation in various types of cells and tissues.

Beginning with an introduction to the discovery of regucalcin, the book then looks at the structure of regucalcin and at translational regulation of the regucalcin gene. Chapters consider the multifunctional role of this protein in cell regulation, including intracellular calcium homeostasis, nuclear function and gene expression, protein synthesis and proteolysis, cell proliferation, apoptosis, and oxidative stress. Furthermore, this book highlights involvements of regucalcin in cell disorder and diseases in implication with liver metabolic disorder, kidney failure, cardiac disorder, brain calcium homeostasis and aging, bone homeostasis and osteoporosis, lipid metabolism and diabetes, and carcinogenesis. Moreover, readers will discover serum regucalcin's potential sensitivity as a specific biochemical marker in various metabolic disorders.



This book contributes to scientific understanding of cell disorder and a variety of diseases and it will be of interest to many researchers and graduate students in the field of biomedical sciences.