A Guide to Sample Size for Animal-based Studies (PDF)
(Sprache: Englisch)
Understand a foundational area of experimental design with this innovative reference
Animal-based research is an essential part of basic and preclinical research, but poses a unique set of experimental design challenges. The most important of these are...
Animal-based research is an essential part of basic and preclinical research, but poses a unique set of experimental design challenges. The most important of these are...
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Understand a foundational area of experimental design with this innovative reference
Animal-based research is an essential part of basic and preclinical research, but poses a unique set of experimental design challenges. The most important of these are the 3Rs Replacement, Reduction and Refinement the principles comprising the ethical framework for humane animal-based studies. However, many researchers have difficulty navigating the design trade-offs necessary to simultaneously minimize animal use, and produce scientific information that is both rigorous and reliable.
A Guide to Sample Size for Animal-Based Studies meets this need with a thorough, accessible reference work to the subject. This book provides a straightforward systematic approach to "right-sizing" animal-based experiments, with sample size estimates based on the fundamentals of statistical thinking: structured research questions, variation control and appropriate design of experiments. The result is a much-needed guide to planning animal-based experiments to ensure scientifically valid and reliable results.
This book offers:
* Step-by-step guidance in diverse methods for approximating and refining sample size
* Detailed treatment of research topics specific to animal-based research, including pilot, feasibility and proof-of-concept studies
* Sample size approximation methods for different types of data binary, continuous, ordinal, time to event and different study types description, comparison, nested designs, reference interval construction and dose-response studies
* Numerous worked examples, using real data from published papers, together with SAS and R code
A Guide to Sample Size for Animal-Based Studies is a must-have reference for preclinical and veterinary researchers, as well as ethical oversight committees and policymakers.
Animal-based research is an essential part of basic and preclinical research, but poses a unique set of experimental design challenges. The most important of these are the 3Rs Replacement, Reduction and Refinement the principles comprising the ethical framework for humane animal-based studies. However, many researchers have difficulty navigating the design trade-offs necessary to simultaneously minimize animal use, and produce scientific information that is both rigorous and reliable.
A Guide to Sample Size for Animal-Based Studies meets this need with a thorough, accessible reference work to the subject. This book provides a straightforward systematic approach to "right-sizing" animal-based experiments, with sample size estimates based on the fundamentals of statistical thinking: structured research questions, variation control and appropriate design of experiments. The result is a much-needed guide to planning animal-based experiments to ensure scientifically valid and reliable results.
This book offers:
* Step-by-step guidance in diverse methods for approximating and refining sample size
* Detailed treatment of research topics specific to animal-based research, including pilot, feasibility and proof-of-concept studies
* Sample size approximation methods for different types of data binary, continuous, ordinal, time to event and different study types description, comparison, nested designs, reference interval construction and dose-response studies
* Numerous worked examples, using real data from published papers, together with SAS and R code
A Guide to Sample Size for Animal-Based Studies is a must-have reference for preclinical and veterinary researchers, as well as ethical oversight committees and policymakers.
Bibliographische Angaben
- Autor: Penny S. Reynolds
- 2023, 1. Auflage, 288 Seiten, Englisch
- Verlag: John Wiley & Sons
- ISBN-10: 1119799996
- ISBN-13: 9781119799993
- Erscheinungsdatum: 31.08.2023
Abhängig von Bildschirmgröße und eingestellter Schriftgröße kann die Seitenzahl auf Ihrem Lesegerät variieren.
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- Größe: 6.22 MB
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Sprache:
Englisch
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