ADME and Translational Pharmacokinetics / Pharmacodynamics of Therapeutic Proteins (ePub)
Applications in Drug Discovery and Development
(Sprache: Englisch)
With an emphasis on the fundamental and practical aspects of ADME for therapeutic proteins, this book helps readers strategize, plan and implement translational research for biologic drugs. Details cutting-edge ADME (absorption, distribution, metabolism...
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With an emphasis on the fundamental and practical aspects of ADME for therapeutic proteins, this book helps readers strategize, plan and implement translational research for biologic drugs. Details cutting-edge ADME (absorption, distribution, metabolism and excretion) and PKPD (pharmacokinetic / pharmacodynamics) modeling for biologic drugs Combines theoretical with practical aspects of ADME in biologic drug discovery and development and compares innovator biologics with biosimilar biologics and small molecules with biologics, giving a lessons-learned perspective Includes case studies about leveraging ADME to improve biologics drug development for monoclonal antibodies, fusion proteins, pegylated proteins, ADCs, bispecifics, and vaccines Presents regulatory expectations and industry perspectives for developing biologic drugs in USA, EU, and Japan Provides mechanistic insight into biodistribution and target-driven pharmacokinetics in important sites of action such as tumors and the brain
Autoren-Porträt von Honghui Zhou, Frank-Peter Theil
Honghui Zhou is a Senior Director and Janssen Fellow, at Janssen Research & Development, LLC and US head of Pharmacological and Translational Modeling. Board-certified by the American Board of Clinical Pharmacology and a Fellow of American Association of Pharmaceutical Scientists (AAPS) and American College of Clinical Pharmacology (ACCP), he has authored 200 peer-reviewed scientific papers, book chapters, and conference abstracts and co-edited the book Drug-Drug Interactions for Therapeutic Biologics (Wiley, 2013).Frank-Peter Theil heads nonclinical development at UCB Biopharma. Dr. Theil has authored and co-authored 40 research publications, three book chapters and he has given numerous invited presentations at national and international scientific meetings. He is a member of the American Association of Pharmaceutical Scientists (AAPS) and American Society of Clinical Pharmacology and Therapeutics (ASCPT).
Bibliographische Angaben
- Autoren: Honghui Zhou , Frank-Peter Theil
- 2015, 1. Auflage, 480 Seiten, Englisch
- Verlag: John Wiley & Sons
- ISBN-10: 1118898745
- ISBN-13: 9781118898741
- Erscheinungsdatum: 26.10.2015
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eBook Informationen
- Dateiformat: ePub
- Größe: 42 MB
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Sprache:
Englisch
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