HSF1 and Molecular Chaperones in Biology and Cancer / Advances in Experimental Medicine and Biology Bd.1243 (PDF)
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The chapters in this book are written by world experts in the many facets of the proteostasis network. They describe cutting-edge insights into the structure and function of the major chaperone and degradation systems in healthy cells and how these systems are co-opted in cancer cells and the cells of the tumor microenvironment. The chapters also cover therapeutic interventions such as the FDA-approved proteasome inhibitors Velcade and Krypolis as well as other therapies currently under clinical investigation to disarm the ability of the proteostasis network to support malignancy. This compendium is the first of its kind and aims to serve as a reference manual for active investigators and a primer for newcomers to the field.
This book is dedicated to the memory of Susan Lindquist, a pioneer of the proteostasis field and a champion of the power of basic scientific inquiry to unlock the mechanisms of human disease.
The chapter "Reflections and Outlook on Targeting HSP90, HSP70 and HSF1 in Cancer: A Personal Perspective" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Dr. Marc Mendillo is an Assistant Professor of Biochemistry and Molecular Genetics at the Northwestern University. His PhD was obtained from the University Of California-San Diego in Biomedical Sciences followed by a Postdoctoral Fellowship at the Ludwig Institute for Cancer Research in San Diego and another at the Whitehead Institute. Currently, he runs a lab in the Department of Biochemistry and Molecular Genetics and the Robert H. Lurie Comprehensive Cancer Center.
Dr. David Pincus is a fellow at the Whitehead Institute where he tries to reveal the underlying mechanisms cells employ to maintain homeostasis in inherently fluctuating environments.
- 2020, 1st ed. 2020, 182 Seiten, Englisch
- Herausgegeben: Marc Laurence Mendillo, David Pincus, Ruth Scherz-Shouval
- Verlag: Springer-Verlag GmbH
- ISBN-10: 3030402045
- ISBN-13: 9783030402044
- Erscheinungsdatum: 15.04.2020
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