Bio-nanoimaging (ePub)
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Bio-Nanoimaging: Protein Misfolding & Aggregation provides a unique introduction to both novel and established nanoimaging techniques for visualization and characterization of misfolded and aggregated protein species. The book is divided into three sections covering: - Nanotechnology and nanoimaging technology, including cryoelectron microscopy of beta(2)-microglobulin, studying amyloidogensis by FRET; and scanning tunneling microscopy of protein deposits - Polymorphisms of protein misfolded and aggregated species, including fibrillar polymorphism, amyloid-like protofibrils, and insulin oligomers - Polymorphisms of misfolding and aggregation processes, including multiple pathways of lysozyme aggregation, misfolded intermediate of a PDZ domain, and micelle formation by human islet amyloid polypeptide
Protein misfolding and aggregation is a fast-growing frontier in molecular medicine and protein chemistry. Related disorders include cataracts, arthritis, cystic fibrosis, late-onset diabetes mellitus, and numerous neurodegenerative diseases like Alzheimer's and Parkinson's. Nanoimaging technology has proved crucial in understanding protein-misfolding pathologies and in potential drug design aimed at the inhibition or reversal of protein aggregation. Using these technologies, researchers can monitor the aggregation process, visualize protein aggregates and analyze their properties.
- Provides practical examples of nanoimaging research from leading molecular biology, cell biology, protein chemistry, biotechnology, genetics, and pharmaceutical labs
- Includes over 200 color images to illustrate the power of various nanoimaging technologies
- Focuses on nanoimaging techniques applied to protein misfolding and aggregation in molecular medicine
He received his B.S. and M.S. degrees in Physics from Leningrad State University in Russia in 1986, then, completed Ph.D. and Doctor of Sciences (D.Sc.) degrees in Physics and Mathematics (field of study - Biophysics) at the Moscow Institute of Physics and Technology (1991) and the Institute Experimental and Theoretical Biophysics of the Russian Academy of Sciences (1998), respectively. He spent his early career working on protein folding at Institute of Protein Research and the Institute for Biological Instrumentation (Russia). In 1998, he moved to the University of California Santa Cruz to study protein folding, misfolding, protein conformation diseases, and protein intrinsic disorder phenomenon. In 2004, he was invited to join the Indiana University School of Medicine to primary work on the intrinsically disordered proteins. Since 2010, he is with USF, where he continues to study intrinsically disordered proteins and analyze protein folding and misfolding processes.
He has authored over 750 scientific publications and edited several books and book series on protein structure, function, folding and misfolding. He is the editor of several scientific journals. In 2014, 2015, 2016, and 2017, he was included by the Thomson Reuters to the list of Highly Cited Researchers.
- 2013, 552 Seiten, Englisch
- Herausgegeben: Vladimir N. Uversky, Yuri Lyubchenko
- Verlag: Elsevier Science & Techn.
- ISBN-10: 0123978211
- ISBN-13: 9780123978219
- Erscheinungsdatum: 05.11.2013
Abhängig von Bildschirmgröße und eingestellter Schriftgröße kann die Seitenzahl auf Ihrem Lesegerät variieren.
- Dateiformat: ePub
- Größe: 23 MB
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