Biopharmaceutics Modeling and Simulations (ePub)

A comprehensive introduction to using modeling and simulation
programs in drug discovery and development

Biopharmaceutical modeling has become integral to the design and
development of new drugs. Influencing key aspects of the
development process, including drug substance design, formulation
design, and toxicological exposure assessment, biopharmaceutical
modeling is now seen as the linchpin to a drug's future success.
And while there are a number of commercially available software
programs for drug modeling, there has not been a single resource
guiding pharmaceutical professionals to the actual tools and
practices needed to design and test safe drugs.

A guide to the basics of modeling and simulation programs,
Biopharmaceutics Modeling and Simulations offers
pharmaceutical scientists the keys to understanding how they work
and are applied in creating drugs with desired medicinal
properties. Beginning with a focus on the oral absorption of drugs,
the book discusses:

* The central dogma of oral drug absorption (the interplay of
dissolution, solubility, and permeability of a drug), which forms
the basis of the biopharmaceutical classification system (BCS)

* The concept of drug concentration

* How to simulate key drug absorption processes

* The physiological and drug property data used for
biopharmaceutical modeling

* Reliable practices for reporting results

With over 200 figures and illustrations and a peerless
examination of all the key aspects of drug research--including
running and interpreting models, validation, and compound and
formulation selection--this reference seamlessly brings
together the proven practical approaches essential to developing
the safe and effective medicines of tomorrow.