Tumor Microenvironment / Cancer Treatment and Research Bd.180 (PDF)
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This book addresses the biological processes relevant to the immune phenotypes of cancer and their significance for immune responsiveness, based on the premise that malignant cells manipulate their surroundings through an evolutionary process that is controlled by interactions with innate immune sensors as well as the adaptive recognition of self/non-self. Checkpoint inhibitor therapy is now an accepted new form of cancer treatment. Other immuno-oncology approaches, such as adoptive cell therapy and metabolic inhibitors, have also shown promising results for specific indications. Immune resistance is common, however, limiting the efficacy of immunotherapy in many common cancer types.
The reasons for such resistance are diverse and peculiar to the immune landscapes of individual cancers, and to the treatment modality used. Accordingly, approaches to circumvent resistance need to take into account context-specific genetic, biological and environmental factors that may affect the cancer immune cycle, and which can best be understood by studying the target tissue and correlated systemic immune markers.
Understanding the major requirements for the evolutionary process governing human cancer growth in the immune-competent host will guide effective therapeutic choices that are tailored to the biology of individual cancers.
Francesco Marincola, M.D. is currently Chief Scientific Officer at Refuge Biotechnologies, Menlo Park, California. He has previously served as a Distinguished Research Fellow at AbbVie Corporation in Redwood City, California; Chief Research Officer at Sidra Medical and Research Center in Doha, Qatar; and Tenured Investigator at the National Institutes of Health, Bethesda, Maryland. Dr. Marincola's research interest lies in translational medicine and focuses on the development of strategies for the dynamic study of patients' response to immunotherapy. His approach has resulted in seminal observations regarding the mechanisms leading to rejection of tumors, allograft rejection, graft-versus-host disease, and autoimmunity. In 2003, Dr. Marincola founded the Journal of Translational Medicine, of which he is currently the Editor-in-Chief. He is also Editor-in-Chief of Translational Medicine
- 2020, 1st ed. 2020, 326 Seiten, Englisch
- Herausgegeben: Peter P. Lee, Francesco M. Marincola
- Verlag: Springer-Verlag GmbH
- ISBN-10: 303038862X
- ISBN-13: 9783030388621
- Erscheinungsdatum: 25.03.2020
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