Chemical Synthesis of Nucleoside Analogues (ePub)
(Sprache: Englisch)
Compiles current tested and proven approaches to
synthesize novel nucleoside analogues
Featuring contributions from leading synthetic chemists from
around the world, this book brings together and describes tested
and proven approaches for the chemical...
synthesize novel nucleoside analogues
Featuring contributions from leading synthetic chemists from
around the world, this book brings together and describes tested
and proven approaches for the chemical...
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Compiles current tested and proven approaches to
synthesize novel nucleoside analogues
Featuring contributions from leading synthetic chemists from
around the world, this book brings together and describes tested
and proven approaches for the chemical synthesis of common families
of nucleoside analogues. Readers will learn to create new
nucleoside analogues with desired therapeutic properties by using a
variety of methods to chemically modify natural nucleosides,
including:
* Changes to the heterocyclic base
* Modification of substituents at the sugar ring
* Replacement of the furanose ring by a different carbo- or
heterocyclic ring
* Introduction of conformational restrictions
* Synthesis of enantiomers
* Preparation of hydrolitically stable C-nucleosides
Chemical Synthesis of Nucleoside Analogues covers all the
major classes of nucleosides, including pronucleotides,
C-nucleosides, carbanucleosides, and PNA monomers which have shown
great promise as starting points for the synthesis of nucleoside
analogues. The book also includes experimental procedures for key
reactions related to the synthesis of nucleoside analogues,
providing a valuable tool for the preparation of a number of
different compounds.
Throughout the book, chemical schemes and figures help readers
better understand the chemical structures of nucleoside analogues
and the methods used to synthesize them. Extensive references serve
as a gateway to the growing body of original research studies and
reviews in the field.
Synthetically modified nucleosides have proven their value as
therapeutic drugs, in particular as antiviral and antitumor agents.
However, many of these nucleoside analogues have undesirable side
effects. With Chemical Synthesis of Nucleoside Analogues as
their guide, researchers have a new tool for synthesizing a new
generation of nucleoside analogues that can be used as therapeutic
drugs with fewer unwanted side effects.
synthesize novel nucleoside analogues
Featuring contributions from leading synthetic chemists from
around the world, this book brings together and describes tested
and proven approaches for the chemical synthesis of common families
of nucleoside analogues. Readers will learn to create new
nucleoside analogues with desired therapeutic properties by using a
variety of methods to chemically modify natural nucleosides,
including:
* Changes to the heterocyclic base
* Modification of substituents at the sugar ring
* Replacement of the furanose ring by a different carbo- or
heterocyclic ring
* Introduction of conformational restrictions
* Synthesis of enantiomers
* Preparation of hydrolitically stable C-nucleosides
Chemical Synthesis of Nucleoside Analogues covers all the
major classes of nucleosides, including pronucleotides,
C-nucleosides, carbanucleosides, and PNA monomers which have shown
great promise as starting points for the synthesis of nucleoside
analogues. The book also includes experimental procedures for key
reactions related to the synthesis of nucleoside analogues,
providing a valuable tool for the preparation of a number of
different compounds.
Throughout the book, chemical schemes and figures help readers
better understand the chemical structures of nucleoside analogues
and the methods used to synthesize them. Extensive references serve
as a gateway to the growing body of original research studies and
reviews in the field.
Synthetically modified nucleosides have proven their value as
therapeutic drugs, in particular as antiviral and antitumor agents.
However, many of these nucleoside analogues have undesirable side
effects. With Chemical Synthesis of Nucleoside Analogues as
their guide, researchers have a new tool for synthesizing a new
generation of nucleoside analogues that can be used as therapeutic
drugs with fewer unwanted side effects.
Autoren-Porträt
PEDRO MERINO, PhD, is the Director of the Department ofSynthesis and Structure of Biomolecules of the Institute of
Chemical Synthesis and Homogenous Catalysis at the University of
Zaragoza. Dr. Merino has authored more than 200 publications,
including several reviews and book chapters. His research spans
asymmetric synthesis, target-oriented synthesis, organometallic
chemistry, and asymmetric metal-assisted and organic catalysis.
Recently, he has been investigating the use of computational
chemistry to better understand reaction mechanisms.
Bibliographische Angaben
- 2013, 1. Auflage, 912 Seiten, Englisch
- Herausgegeben: Pedro Merino
- Verlag: John Wiley & Sons
- ISBN-10: 1118498100
- ISBN-13: 9781118498101
- Erscheinungsdatum: 12.02.2013
Abhängig von Bildschirmgröße und eingestellter Schriftgröße kann die Seitenzahl auf Ihrem Lesegerät variieren.
eBook Informationen
- Dateiformat: ePub
- Größe: 49 MB
- Mit Kopierschutz
Sprache:
Englisch
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