Collateral Circulation of the Heart (PDF)

Cardiovascular diseases are the leading cause of death in industrialized countries. Established options for revascularization include angioplasty and surgical bypass, both of which are unsuitable in 20-30% of patients in whom the extent of coronary atherosclerosis is especially severe. An alternative treatment strategy for revascularization is therefore warranted both to control symptoms as well as to alter the course of advanced coronary artery disease. An ideal candidate to fill in this gap is therapeutic promotion of coronary collateral growth, that is, the induction of natural anastomoses of ischemic areas. In order to reach this goal, a comprehensive understanding of the human coronary collateral circulation with regard to its relevance, accurate assessment, the pathogenetic and pathophysiological aspects, and the different therapeutic options is mandatory.

Collateral Circulation of the Heart focuses on the practical aspects of human coronary collateral vessels. It includes explanation of the basic science and pathophysiological aspects, as the clinical aspects cannot be fully understood without a thorough grounding in the physiology of the formation of collaterals. Professor Seiler, an international expert on the subject, has written this authoritative reference to provide a comprehensive review of the topic, its impact and clinical relevance. Suitable for all cardiologists, cardiovascular radiologists, internal medicine and critical care physicians, students of cardiovascular medicine and human physiologists, the book contains many stunning illustrations that give a flavor of the huge variability in collateral vessel formation, including all the relevant imaging modalities, and the possibilities of alleviating ischemic symptoms in many patients.