Colloquium Series on Integrated Systems Physiology: From Molecule to Function: Pathogenesis of Atherosclerosis (PDF)
From Cell Biology to Therapeutics
(Sprache: Englisch)
The circulatory system provides the tissues of the body with oxygen and nutrients for survival, allows for the dissemination of inflammatory cells, and clears metabolic waste from building up and damaging tissue. Atherosclerotic disease, the build-up of...
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The circulatory system provides the tissues of the body with oxygen and nutrients for survival, allows for the dissemination of inflammatory cells, and clears metabolic waste from building up and damaging tissue. Atherosclerotic disease, the build-up of fat, inflammatory cells, and fibrotic tissue in the vessel wall, hinders this function, resulting in inadequate perfusion of the target tissue. Hypoxia, or lack of oxygen, rapidly results in cellular dysfunction that profoundly affects the functionality of the overall tissue. Atherosclerosis-associated tissue ischemia and hypoxia because of loss of blood flow underlies several significant disease pathologies including ischemic heart disease, stroke, and peripheral artery disease. In this eBook, we examine the process of atherosclerotic plaque formation both at the cellular level and the level of clinical presentation. Through this book, we hope to impart to the reader a better understanding of how vessel structure, environmental risk factors, and genetic predisposition contribute to atherosclerotic disease and how current and future therapies seek to circumvent the cellular processes contributing to plaque formation to reduce atherosclerotic plaque burden and clinical complications.
Table of Contents: List of Videos / Introduction to Atherosclerosis / Epidemiology / Endothelial Cell Activation and Arterial Hemodynamics / Cholesterol and Cardiovascular Disease / Inflammation in Atherosclerosis / Smooth Muscle Cells and Plaque Vulnerability / Diagnosing Atherosclerotic Disease / Treatment and Prevention / Summary and Future Perspectives / References / Author Biographies
Table of Contents: List of Videos / Introduction to Atherosclerosis / Epidemiology / Endothelial Cell Activation and Arterial Hemodynamics / Cholesterol and Cardiovascular Disease / Inflammation in Atherosclerosis / Smooth Muscle Cells and Plaque Vulnerability / Diagnosing Atherosclerotic Disease / Treatment and Prevention / Summary and Future Perspectives / References / Author Biographies
Autoren-Porträt von A. Wayne Orr, Arif Yurdagul Jr., Brijesh M. Patel
Departments of Pathology and Cell Biology and Anatomy LSU Health Sciences Center – ShreveportDepartments of Pathology and Cell Biology and Anatomy LSU Health Sciences Center – Shreveport
Department of Medicine Division of Cardiology LSU Health Sciences Center – Shreveport
Bibliographische Angaben
- Autoren: A. Wayne Orr , Arif Yurdagul Jr. , Brijesh M. Patel
- 2014, 125 Seiten, Englisch
- Verlag: Biota Publishing
- ISBN-10: 1615046577
- ISBN-13: 9781615046577
- Erscheinungsdatum: 01.07.2014
Abhängig von Bildschirmgröße und eingestellter Schriftgröße kann die Seitenzahl auf Ihrem Lesegerät variieren.
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- Dateiformat: PDF
- Größe: 12 MB
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Sprache:
Englisch
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