Combinatorial Synthesis of Natural Product-Based Libraries (PDF)

Armen M. Boldi received his B.A. degree in chemistry from Occidental College in Los Angeles, California. He earned his Ph.D. in chemistry from the University of California at Los Angeles (UCLA), working with François Diederich. He went on to the University of Pennsylvania to work as a National Institutes of Health (NIH) postdoctoral fellow with Amos B. Smith, III, on the total synthesis of the spongistatins. In 1997, he joined the drug discovery efforts of Arris Pharmaceutical (now Applera Corporation-Celera Genomics Group) in the combinatorial chemistry group. Dr. Boldi was actively involved with the development and growth of this group, which developed first into a division and subsequently into a wholly owned subsidiary. The combinatorial chemistry business unit located in South San Francisco was subsequently acquired by Discovery Partners International in 2001. He continued to work at Discovery Partners International in the chemistry division on numerous library programs with pharmaceutical and biotech companies in the United States, Europe, and Japan. Acting as director of project management, he managed various synthetic chemistry collaborations. He recently moved to Codexis, Inc., Redwood City, California, to serve as manager of research and development operations. For the past nine years, his group has focused on the development and the application of synthetic methodologies to the generation of discovery libraries and targeted libraries for lead identification. His research interests span the various disciplines in the drug discovery process including medicinal, combinatorial, and synthetic chemistry. He has a special interest in integrating small-molecule natural product-based libraries into lead discovery programs. Dr. Boldi has published over 20 technical papers in the areas of synthetic organic chemistry and combinatorial chemistry.

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