Concepts and Models for Drug Permeability Studies (ePub)

Name: Concepts and Models for Drug Permeability Studies
Brand: Elsevier Science & Techn.
SKU: 70271325
Price: 148.00 EUR
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Cell and Tissue based In Vitro Culture Models (Sprache: Englisch)

Autor: Bruno Sarmento

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Concepts and Models for Drug Permeability Studies, Bruno Sarmento

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This book intends to be an updated compilation of the most important buccal, gastric, intestinal, pulmonary, nasal, vaginal, ocular, skin and blood-brain barrier in vitro models for predicting the permeability of drugs. Concepts and Models for Drug Permeability Studies focuses on different approaches and comprises of various models. Each model describes the protocol of seeding and conservation, the application for specific drugs, and takes into account the maintenance of physiologic characteristics and functionality of epithelium, from the simplest immortalized cell-based monoculture to the most complex engineered-tissue models. Chapters also discuss the equivalence between in vitro cell and tissue models and in vivo conditions, highlighting how each model may provisionally resemble a different drug absorption route.

Updated information regarding the most recent in vitro models to study the permeability of drugs
Short and concise chapters covering all the biological barriers with interest in drug permeability
A combination of bibliographic information related with individual models and footnote instructions of technical procedures for construction of cell and tissue-based models
Simple and clear scientific content, adaptable for young scientists and experimented researchers

Autoren-Porträt von Bruno Sarmento

Bruno Sarmento is an Affiliated Investigator at the INEB-Instituto de Engenharia Biomédica, based at the University of Porto, Portugal and is Assistant Professor of Pharmaceutical Technology in the Department of Pharmaceutical Sciences, at ISCS-N, Gandra, Portugal. His current research is focused on the study of nanomedicines and their application in the pharmaceutical and biomedical fields, as well as the use of in vitro cell models as a tool to correlate the transport of biopharmaceuticals and nanoparticles across human mucosa. Bruno has been involved with more than two hundred publications, including three edited books in the field of Pharmaceutical Technology and Nanomedicine, more than one hundred papers in international peer-review journals and several conference proceedings. He also serves as an editorial board member for several international journals and an evaluator of research projects form international agencies. He is an active member of several international associations (AAPS, CRS, EUFEPS, EFSD, FIP) and works on biotechnology and health post-graduate programs at national and international level.

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Bibliographische Angaben

Autor: Bruno Sarmento
2015, 408 Seiten, Englisch
Verlag: Elsevier Science & Techn.
ISBN-10: 0081001142
ISBN-13: 9780081001141
Erscheinungsdatum: 30.09.2015

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Dateiformat: ePub
Größe: 11 MB
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Englisch

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