Drug Efficacy, Safety, and Biologics Discovery / Wiley Series on Technologies for the Pharmaceutical (PDF)

Preface. Acknowledgments. Contributors. PART I: DRUG EFFICACY AND SAFETY TECHNOLOGY. 1. Focus on Fundamentals: Towards Better Therapeutic Index Prediction (Jinghai J. Xu and Li J. Yu). 2. High-Throughput Protein-Based Technologies and Computational Models for Drug Development, Efficacy and Toxicity (Leonidas G. Alexopoulos, Julio Saez-Rodriguez and Christopher W. Espelin). 3. Cellular Systems Biology Applied to Pre-Clinical Safety Testing: A Case Study of CellCiphr¯TM Profiling (Lawrence Vernetti, William Irwin, Kenneth A. Giuliano, Albert Gough, Kate Johnston and D. Lansing Taylor). 4. Systems Pharmacology, Biomarkers and Biomolecular Networks (Aram Adourian, Thomas N. Plasterer, Raji Balasubramanian, Ezra Jennings, Shunguang Wang, Jan van der Greef, Robert McBurney, Pieter Muntendam, and Noubar Afeyan). 5. Zebrafish Models for Human Diseases and Drug Discovery (Hanbing Zhong, Ning-Ai Liu and Shuo Lin). 6. Toxicity Pathways and Models: Mining for Potential Side Effects (Sean Ekins and Josef Scheiber). 7. Computational Systems Biology Modeling of Dosimetry and Cellular Response Pathways (Qiang Zhang, Yu-Mei Tan, Sudin Bhattacharya and Melvin E. Andersen). 8. Stem Cell Technology for Embryotoxicity, Cardiotoxicity and Hepatotoxicity Evaluation (Julio C. Davila, Donald B. Stedman, Sandra J. Engle, Howard I. Pryor II and Joseph P. Vacanti). 9. Telemetry Technology for Preclinical Drug Discovery and Development (Yi Yang). PART II. BIOLOGICS TECHNOLOGY. 10. Nanotechnology to Improve Oral Drug Delivery (Mayank D. Bhavsar, Shardool Jain, and Mansoor M. Amiji). 11. Functional Glycomics and the Future of Glycomic Drugs (Ram Sasisekharan). 12. Modeling Efficacy and Safety of Engineered Biologics (Jeff Chabot and Bruce Gomes). 13. Regulation of Gene Expression by Small, Non-Coding RNAs: Practical Applications (Roman Herrara and Eric Tien). PART III. FUTURE PERSPECTIVE. 14. Future Perspectives of Biological Engineering in Pharmaceutical Research: The Paradigm of Modeling,

Sean Ekins, MSc, PHD, DSc, is the Principal at Collaborations in
Chemistry; and Adjunct Associate Professor in the Department of
Pharmaceutical Sciences at the University of Maryland, School of
Pharmacy. Dr. Ekins has published widely on ADME/Tox, systems
biology, computational, and in vitro drug discovery approaches. He
has previously edited two Wiley books: Computer Applications in
Pharmaceutical Research and Development (2006) and Computational
Toxicology: Risk Assessment for Pharmaceutical and Environmental
Chemicals (2007).

Jinghai J. Xu, PHD, is Director of Automated Biotechnology at
Merck. Previously he headed predictive toxicology at Pfizer, where
he led research activities in drug-induced liver injury, genetic
toxicology, drug transporters, assay development, high content
screening, in vitro in vivo correlations, systems biology, and
systems toxicology. Dr. Xu has served on steering committees of
academic-industry and industry-industry collaborations, and as a
guest lecturer at the Massachusetts Institute of Technology.

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