Drugs, Addiction, and the Brain (ePub)
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Drugs, Addiction, and the Brain explores the molecular, cellular, and neurocircuitry systems in the brain that are responsible for drug addiction. Common neurobiological elements are emphasized that provide novel insights into how the brain mediates the acute rewarding effects of drugs of abuse and how it changes during the transition from initial drug use to compulsive drug use and addiction. The book provides a detailed overview of the pathophysiology of the disease. The information provided will be useful for neuroscientists in the field of addiction, drug abuse treatment providers, and undergraduate and postgraduate students who are interested in learning the diverse effects of drugs of abuse on the brain.
- Full-color circuitry diagrams of brain regions implicated in each stage of the addiction cycle
- Actual data figures from original sources illustrating key concepts and findings
- Introduction to basic neuropharmacology terms and concepts
- Introduction to numerous animal models used to study diverse aspects of drug use.
- Thorough review of extant work on the neurobiology of addiction
Dr. Koob's research interests have been directed at the
Dr. Koob also is one of the world's authorities on the neurobiology of drug addiction. He has contributed to our understanding of the neurocircuitry associated with the acute reinforcing effects of drugs of abuse and more recently on the neuroadaptations of these reward circuits associated with the transition to dependence. He has validated key animal models for dependence associated with drugs of abuse and has begun to explore a key role of anti-reward systems in the development of dependence.
Dr. Koob's work with the neurobiology of stress includes the characterization of behavioral functions in the central nervous system for catecholamines, opioid peptides, and corticotropin-releasing factor. Corticotropin-releasing factor, in addition to its classical hormonal functions in the hypothalamic-pituitary-adrenal axis, is also located in extrahypothalamic brain structures and may have an important role in brain emotional function. Recent use of specific corticotropin-releasing factor antagonists suggests that endogenous brain corticotropin-releasing factor may be involved in specific behavioral responses to stress, the psychopathology of anxiety and affective disorders, and drug addiction.
- Autoren: George F. Koob , Michael A. Arends , Michel Le Moal
- 2014, 350 Seiten, Englisch
- Verlag: Elsevier Science & Techn.
- ISBN-10: 0123869595
- ISBN-13: 9780123869593
- Erscheinungsdatum: 12.07.2014
Abhängig von Bildschirmgröße und eingestellter Schriftgröße kann die Seitenzahl auf Ihrem Lesegerät variieren.
- Dateiformat: ePub
- Größe: 19 MB
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