Free Radical Toxicology (ePub)

Free Radical Toxicology: The Harmful and Beneficial Effects of Redox Cycling Chemicals presents an overview of current thinking on the harmful and beneficial effects of the aromatic compounds that generate free radicals through redox cycling. It is known that certain toxic compounds can undergo redox cycling. The re-oxidization stage of this cycle leads to the formation of reactive oxygen species, responsible for the majority of toxic effects of these chemicals in vivo. Free Radical Toxicology describes the present understanding of the toxic effects of these compounds and explores emerging research into their therapeutic potential in the use of anti-cancer drugs, and the potential treatment for malaria and other parasitic diseases.Written by a world-leading expert in the field, Free Radical Toxicology presents a systematic approach to researching redox cycling compounds, their background, instances of exposure, hazards, toxicological end points and practical guidance on assays.Provides a full description of the aromatic compounds that undergo redox cycling, their occurrence and toxicological effectsComprehensively reviews the target organs of these compounds and the reasons for their tissue specificityOffers a risk-based approach to the potential therapeutic use of free radical generating compounds