Integrated Strategies for Drug Discovery Using Mass Spectrometry / Wiley Series on Pharmaceutical Science (PDF)
(Sprache: Englisch)
New strategies and techniques for today's fast-paced discovery
process
Today, the pressure is on for high-throughput approaches to
accelerate the generation, identification, and optimization of
molecules with desirable drug properties. As traditional...
process
Today, the pressure is on for high-throughput approaches to
accelerate the generation, identification, and optimization of
molecules with desirable drug properties. As traditional...
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New strategies and techniques for today's fast-paced discovery
process
Today, the pressure is on for high-throughput approaches to
accelerate the generation, identification, and optimization of
molecules with desirable drug properties. As traditional methods of
analysis become antiquated, new analytical strategies and
techniques are necessary to meet sample throughput requirements and
manpower constraints. Among them, mass spectrometry has grown to be
a front-line tool throughout drug discovery.
Integrated Strategies for Drug Discovery Using Mass Spectrometry
provides a thorough review of current analytical approaches,
industry practices, and strategies in drug discovery. The topics
represent current industry benchmarks in specific drug discovery
activities that deal with proteomics, biomarker discovery,
metabonomic approaches for toxicity screening, lead identification,
compound libraries, quantitative bioanalytical support,
biotransformation, reactive metabolite characterization, lead
optimization, pharmaceutical property profiling, sample preparation
strategies, and automation.
THIS BOOK:
* Clearly explains how drug discovery and mass spectrometry are
interconnected
* Discusses the uses and limitations of various types of mass
spectrometry in various aspects of drug discovery
* Prominently features analytical applications that require
trace-mixture analysis
* Provides industry applications and real-world examples
* Shares historical background information on various techniques to
aid in the understanding of how and why new methods are now being
employed to analyze samples
process
Today, the pressure is on for high-throughput approaches to
accelerate the generation, identification, and optimization of
molecules with desirable drug properties. As traditional methods of
analysis become antiquated, new analytical strategies and
techniques are necessary to meet sample throughput requirements and
manpower constraints. Among them, mass spectrometry has grown to be
a front-line tool throughout drug discovery.
Integrated Strategies for Drug Discovery Using Mass Spectrometry
provides a thorough review of current analytical approaches,
industry practices, and strategies in drug discovery. The topics
represent current industry benchmarks in specific drug discovery
activities that deal with proteomics, biomarker discovery,
metabonomic approaches for toxicity screening, lead identification,
compound libraries, quantitative bioanalytical support,
biotransformation, reactive metabolite characterization, lead
optimization, pharmaceutical property profiling, sample preparation
strategies, and automation.
THIS BOOK:
* Clearly explains how drug discovery and mass spectrometry are
interconnected
* Discusses the uses and limitations of various types of mass
spectrometry in various aspects of drug discovery
* Prominently features analytical applications that require
trace-mixture analysis
* Provides industry applications and real-world examples
* Shares historical background information on various techniques to
aid in the understanding of how and why new methods are now being
employed to analyze samples
Inhaltsverzeichnis zu „Integrated Strategies for Drug Discovery Using Mass Spectrometry / Wiley Series on Pharmaceutical Science (PDF)“
Preface. List of Contributors. Acknowledgements. 1. Miniaturized Formats for Efficient Liquid Chromatography Mass Spectrometry-Based Proteomics and Therapeutic Development. (Gary A. Valaskovic and Neil L. Kelleher). 2. Mass-Spectrometry-Based Drug Screening Assays for Early Phases in Drug Discovery. (Marshall M. Siegel). 3. ESI-FTICR as a High Throughput Drug Discovery Platform. (Kristin A. Sannes-Lowery, Lendell L. Cummins, Shuo Chen, Jared J. Drader, and Steven A. Hofstadler). 4. Mass Spectrometry- Based Proteomic Approaches for Disease Diagnosis and Biomarker Discovery. (Thomas P. Conrads, Haleem J. Issaq, Josi S. Blonder, and Timothy D. Veenstra). 5. Metabonomic Applications in Toxicity Screening and Disease Diagnosis. (John P. Shockcor and Elaine Holmes). 6. The Central Role of Mass Spectrometry in Natural Products Discovery. (Jeffrey R. Gilbert, Paul Lewer, Dennis O. Duebelbeis, Andrew W. Carr). 7. Application of Mass Spectrometry to Compound Library Generation, Analysis, and Management. (Xueheng Cheng and Jill Hochlowski). 8. A Combinatorial Process for Drug Discovery. (David S. Wagner, Richard W. Wagner, Frank Schoenen, and H. Mario Geysen). 9. Application of Technological Advances in Biotransformation Studies. (Carmen L. Fernàndez-Metzler, Raju Subramanian and Richard C. King). 10. Applications of Mass Spectrometry for the Characterization of Reactive Metabolites of Drugs in Discovery. (Jim Wang, Jack Wang, Margaret Davis, William DeMaio, JoAnn Scatina, and Rasmy Talaat). 11. Advances in High Throughput Quantitative Drug Discovery Bioanalysis. (Bradley L. Ackermann, Michael J. Berna, and Anthony T. Murphy). 12. New Strategies for the Implementation and Support of Bioanalysis in a Drug Metabolism Environment. (Walter A. Korfmacher). 13. An Integrated LC-MS Strategy for Preclinical Candidate Optimization. (Jonathan L. Josephs and Mark Sanders). 14. New Approaches for Method Development and Purification in Lead Optimization. (Yining Zhao and David J. Semin).
... mehr
15. High Throughput Metabolic and Physicochemical Property Analysis: Strategies and Tactics for Impact on Drug Discovery Success. (Edward H. Kerns and Li Di). 16. Organ Perfusion and Mass Spectrometry. (C. Gerald Curtis, Ben Chien, David Bar-Or, and Kumar Ramu). 17. Sample Preparation for Drug Discovery Bioanalysis.(David A. Wells). 18. Automation. (John D. Laycock and Thomas Hartmann). Index.
... weniger
Autoren-Porträt von Mike S. Lee
MIKE S. LEE, PHD is President of Milestone Development Services. He is actively involved with consulting, workshops, and symposia to connect industry needs with innovative technologies and solutions. His research interests include the applications of mass spectrometry for the analysis of proteins, natural products, drug metabolites, impurities, and degradants. Recent work has involved the development of automated orthogonal control systems for electrospray ionization. Formerly, Dr. Lee was director of analytical research and development at Bristol-Myers Squibb (BMS) Pharmaceutical Research Institute where he led interdisciplinary teams that contributed to the Food and Drug Administration's approval of Buspar® and Serzone, and the accelerated development and approval of TAXOL. Dr. Lee is a member of the American Society of Mass Spectrometry, American Association of Pharmaceutical Scientists, and the American Chemical Society. In addition, he has authored over forty scientific papers and issued patents.
Bibliographische Angaben
- Autor: Mike S. Lee
- 2005, 1. Auflage, 576 Seiten, Englisch
- Verlag: John Wiley & Sons
- ISBN-10: 0471721026
- ISBN-13: 9780471721024
- Erscheinungsdatum: 19.08.2005
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