Metal Complex - DNA Interactions (PDF)
(Sprache: Englisch)
Metal ions and metal complexes have long been recognized as
critically important components of nucleic acid chemistry, both in
regulation of gene expression and as promising therapeutic agents.
Understanding how metal complexes interact with DNA has...
critically important components of nucleic acid chemistry, both in
regulation of gene expression and as promising therapeutic agents.
Understanding how metal complexes interact with DNA has...
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Metal ions and metal complexes have long been recognized as
critically important components of nucleic acid chemistry, both in
regulation of gene expression and as promising therapeutic agents.
Understanding how metal complexes interact with DNA has become an
active research area at the interface between chemistry, molecular
biology and medicine.
Metal Complex - DNA Interactions provides a comprehensive
overview of this increasingly diverse field, presenting recent
developments and the latest research with particular emphasis on
metal-based drugs and metal ion toxicity. The text is divided into
four parts:
* Basic Structural and Kinetic Aspects: includes chapters
on sequence-selective metal binding to DNA and thermodynamic
models.
* Medical Applications: focuses on anticancer platinum
drugs, including discussions on DNA repair in antitumor effects of
platinum drugs and photo-dynamic therapy.
* DNA-Recognition - Nucleases and Sensor: describes
probes for DNA recognition, artificial restriction agents,
metallo-DNAzymes for metal sensing applications and metal ion
dependent catalysis in nucleic acid enzymes.
* Toxicological Aspects: deals with structural studies of
mercury-DNA interactions, chromium-induced DNA damage and
repair, and the effect of arsenic and nickel on DNA
integrity.
This book will be a valuable resource for academic researchers
and professionals from a range of pharmaceutical and chemical
industries, particularly those involved in the development of new
and less toxic anticancer metallo-drugs, and in the field of
environmental and toxicological chemistry.
critically important components of nucleic acid chemistry, both in
regulation of gene expression and as promising therapeutic agents.
Understanding how metal complexes interact with DNA has become an
active research area at the interface between chemistry, molecular
biology and medicine.
Metal Complex - DNA Interactions provides a comprehensive
overview of this increasingly diverse field, presenting recent
developments and the latest research with particular emphasis on
metal-based drugs and metal ion toxicity. The text is divided into
four parts:
* Basic Structural and Kinetic Aspects: includes chapters
on sequence-selective metal binding to DNA and thermodynamic
models.
* Medical Applications: focuses on anticancer platinum
drugs, including discussions on DNA repair in antitumor effects of
platinum drugs and photo-dynamic therapy.
* DNA-Recognition - Nucleases and Sensor: describes
probes for DNA recognition, artificial restriction agents,
metallo-DNAzymes for metal sensing applications and metal ion
dependent catalysis in nucleic acid enzymes.
* Toxicological Aspects: deals with structural studies of
mercury-DNA interactions, chromium-induced DNA damage and
repair, and the effect of arsenic and nickel on DNA
integrity.
This book will be a valuable resource for academic researchers
and professionals from a range of pharmaceutical and chemical
industries, particularly those involved in the development of new
and less toxic anticancer metallo-drugs, and in the field of
environmental and toxicological chemistry.
Inhaltsverzeichnis zu „Metal Complex - DNA Interactions (PDF)“
A Basic Structural and Kinetic Aspects 1. Sequence-Selective Binding of Transition Metal Complexes to DNA 2. Thermodynamic Models of Metal Ion -DNA.Interactions 3. Metal Ion Coordination in G-quadruplexes 4. Supramolecular Chemistry of Metal-Nucleobase Complexes B Medical Applications 5. Platinum Drugs, Nucleotides, and DNA: the Role of Interligand Interactions, nucleotides and DNA 6. Role of DNA Repair in Antitumor Effects of Platinum Drugs 7. Telomeres and Telomerase: Potential Targets for Platinum Complexes 8. Toward Photodynamic Therapy of Cancer with Platinum Group Metal Polyazine Complexes 9. Platinated Oligonucleotides: Synthesis and Applications for the Control of Gene Expression 10. New Titanium and Ruthenium Anticancer Drugs and their Interaction with DNA C DNA-Recognition - Nucleases and Sensors 11. Groove-Binding Ruthenium(II) Complexes as Probes of DNA Recognition 12. DNA Recognition and Binding by Peptide-Metal Complex conjugate 13. Artificial Restriction Agents - Hydrolytic Agents for DNA Cleavage 14. New Metallo-DNAzymes: Fundamental Studies of Metal-DNA Interactions and Metal Sensing Applications 15. Two-metal Ion Dependent Catalysis in Nucleic Acid Enzymes D Toxicological aspects 16. Mercury- DNA Interactions. Structural Studies on Mercury¯II -Mediated T-T Base-Pair with NMR Spectroscopy 17. Chromium-Induced DNA Damage and Repair 18. Arsenic and nickel: Mechanisms Affecting DNA Integrity
Autoren-Porträt
Nikolaos Hadjiliadis is Professor in the Dept of Chemistry at the University of Ioannina, Greece. Einar Sletten is Professor in the Dept of Chemistry at the University of Bergen, Norway.
Bibliographische Angaben
- 2009, 1. Auflage, 544 Seiten, Englisch
- Herausgegeben: Nick Hadjiliadis, Einar Sletten
- Verlag: John Wiley & Sons
- ISBN-10: 1405194103
- ISBN-13: 9781405194105
- Erscheinungsdatum: 30.03.2009
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