Metalloproteomics / Wiley Series in Protein and Peptide Science (PDF)

Synthesizes the current knowledge in the field and provides new
insights into medical applications

Metalloproteomics is the large-scale study of metal-binding
proteins. These proteins, which represent about one quarter of all
the proteins in the Protein Data Bank, play important roles in all
biological systems and all biological processes.
Metalloproteomics provides the latest information on all
major families of metal-binding proteins, including their
structural, physico-chemical, and functional properties, enabling
readers to better understand these proteins. Moreover, the book
demonstrates how understanding the structures, properties, and
functions of intracellular and extracellular metal-binding proteins
may unlock the key to drug development for the treatment of a
myriad of diseases.

Written by Eugene Permyakov, an international expert and pioneer
in the structural analysis of metal-binding proteins, the book
offers

* Theoretical introduction to cation binding

* Broad range of methods for investigating the binding of
different cations to proteins

* Characteristics of interactions of physiologically important
cations of Ca, Mg, Zn, Fe, Mn, Co, Cu, Ni, Mo, W, Na, and K with
proteins

* Detailed considerations of structural and physico-chemical
properties of the metal-binding proteins

* Interactions of all other metal cations with proteins

* Interactions of different types of cations with nucleic
acids

Throughout the text, the author integrates principles of
proteomics. In addition, detailed examples underscore the role
metal-binding proteins play in health and medicine.

Bringing together and analyzing all the latest findings,
Metalloproteomics' scope and level of insight are
unparalleled. It is recommended for biophysicists, biochemists,
enzymologists, cell and molecular biologists, protein and peptide
scientists, organic and bioinorganic chemists, and chemical
biologists.