Mycobacterium Tuberculosis: Molecular Infection Biology, Pathogenesis, Diagnostics and New Interventions (PDF)
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This book reviews recent advances in the molecular and infection biology, pathology, and molecular epidemiology of Mycobacterium tuberculosis, as well as the identification and validation of novel molecular drug targets for the treatment of this mycobacterial disease.
Despite being completely curable, tuberculosis is still one of the leading global causes of death. M. tuberculosis, the causative organism - one of the smartest pathogens known - adopts highly intelligent strategies for survival and pathogenesis.
Presenting a wealth of information on the molecular infection biology of M. tuberculosis, as well as nontuberculous mycobacteria (NTM), the book provides an overview of the functional role of the PE/PPE group of proteins, which is exclusive to the genus Mycobacteria, of host-pathogen interactions, and virulence. It also explores the pathogenesis of the infection, pathology, epidemiology, and diagnosis of NTM. Finally it discusses current and novel approaches in vaccine development against tuberculosis, including the role of nanotechnology.
With state-of-the-art contributions from experts in the respective domains, this book is an informative resource for practitioners as well as medical postgraduate students and researchers.
Dr. Nasreen Zafar Ehtesham received her Master's from Aligarh Muslim University, Aligarh and graduate training from the University of Alberta, Edmonton, Canada. She pursued her Ph.D. at the National Institute of Immunology, New Delhi (1991) and joined the ICGEB as a Rockefeller Postdoc Fellow. She was appointed as Deputy Director, National Institute of Nutrition, Hyderabad where her group focused on nutrition and inflammation biology. She established the link between pathogenesis, inflammation and stress response using the Mycobacterium tuberculosis infection model. An elected Fellow of the National Academy of Sciences, she has served as a member of several decision-making bodies of the Health Ministry, S&T Ministry. She is the recipient of many awards, including the ICMR-Kshanika Oration Award for her contributions to tuberculosis biology. She has published over 70
Dr. Sonam Grover is a UGC-Assistant Professor at JH-Institute of Molecular Medicine, Jamia Hamdard, New Delhi. She completed her Ph.D. at JNU (2014) and joined Kusuma School of Biological Sciences, IIT Delhi as a Postdoctoral Fellow the same year. During this tenure, she received a Women Scientist Grant from the Department of Health Research, Govt of India. Her main areas of research include Mycobacterium tuberculosis host-pathogen interactions, drug repurposing and identifying novel drug targets against tuberculosis. She has published over 25 research papers in various international, peer-reviewed journals including mBio and Molecular Neurobiology. She has delivered talks and presented her work at several national and international conferences and symposia. She is PI/CoPI in research projects funded by agencies such as DBT and DHR. She was also awarded the prestigious 'ASCB Travel Award for graduate students' to present her research at international conferences.
- 2019, 1st ed. 2019, 514 Seiten, Englisch
- Herausgegeben: Seyed Ehtesham Hasnain, Nasreen Z. Ehtesham, Sonam Grover
- Verlag: Springer-Verlag GmbH
- ISBN-10: 9813294132
- ISBN-13: 9789813294134
- Erscheinungsdatum: 30.11.2019
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- Größe: 10 MB
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