Myofibrillogenesis / Cardiovascular Molecular Morphogenesis (PDF)

Myofibrillogenesis has been studied extensively over the last 100
years. Until recently, we have not had a comprehensive understanding
of this fundamental process. The emergence of new technologies in
molecular and cellular biology, combined with classical embryology,
have started to unravel some of the complexities of myofibril assembly
in striated muscles.
In striated muscles, the contractile proteins are arranged in a highly
ordered three dimensional lattice known as the sarcomere. The assembly
of a myofibril involves the precise ordering of several proteins into
a linear array of sarcomeres. Multiple isoforms in many of these
proteins further complicate the process, making it difficult to define
the precise role of each component. This volume has been compiled as a
comprehensive reference on myofibrillogenesis.
In addition, the book includes reviews on myofibrillar disarray under
various pathological conditions, such as familial hypertrophic
cardiomyopathy (FHC), and incorporates a section on the conduction
system in the heart. Much of the information in this volume has not
been described elsewhere. Presented in a manner to be of value to
students and teachers alike, "Myofibrillogenesis" will be an
invaluable reference source for all in the fields of muscle biology
and heart development.