New Treatment Strategies for Dengue and Other Flaviviral Diseases (PDF)

Dengue virus is a member of the Flaviviridae family, which includes
viruses associated with human diseases such as yellow fever,
Japanese encephalitis and hepatitis C. Dengue fever is
transmitted by mosquitoes, principally Aedes aegypti. There
are four serotypes of dengue virus, of which DENV-2 has been the
most prevalent in many recent epidemics. Following primary
infection, lifelong immunity develops, preventing repeated assault
by the same serotype. However, the non-neutralizing antibodies from
a previous infection or maternally acquired antibodies are thought
to form complexes with a different serotype during a subsequent
infection and cause dengue haemorrhagic fever/dengue shock
syndrome, which can be fatal. There is no treatment or vaccine
available today that can combat this emerging and uncontrolled
disease.

This book features contributions from the world's leading
researchers working on dengue and related flaviviruses who examine
the current state of the art in the molecular biology of the dengue
virus. Particular emphasis is placed on the structure and function
of the virus and the targeting of virus proteins by potential
antiviral agents. The pathogenesis of dengue and dengue
haemorrhagic fever are discussed in detail, especially the target
cells and the specific receptors on these cells, thereby developing
a clear overview of host and viral factors that contribute to
dengue haemorrhagic fever. Finally, the book reviews the
therapeutic options, paying particular attention to ways in which
vector, host and environment can play a critical role in the spread
of this disease.

With dengue fever and other emerging viral diseases becoming
increasingly prevalent around the world, this book provides
valuable insight into the virus that causes this disease and
potential ways to manage it. It is essential reading
for all those working in tropical diseases, public health and
virology.

Praise from the reviews:

"The book provides an excellent summary of dengue/flavivirus
research and is important for individuals and institutions
interested in emerging infectious diseases." MICROBIOLOGY
TODAY